Evidence map›Paper›PMID 41436407›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Nuclear Factor I-B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription.

Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu and 5 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Qianqian ChenDepartment of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Fajuan RuiDepartment of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Zhiwen FanDepartment of Pathology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Hongju YangDivision of Geriatric Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Nan GengDepartment of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Chenqi LuDepartment of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Wenjing NiDepartment of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Yue HuanJiangsu Key Laboratory of Oral Diseases, Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Department of General Dentistry Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, Jiangsu, China.
Junping ShiDepartment of Infectious & Hepatology Diseases, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China.
Chao WuDepartment of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Shengxia YinDepartment of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Wei AnDepartment of Cell Biology, Capital Medical University and the Municipal Key Laboratory for Liver Protection and Regulation of Regeneration, Beijing, China.
Xia LuDepartment of Cardiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong, University School of Medicine, Shanghai, China.
Qianwen ZhaoDepartment of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Jie LiDepartment of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.ORCID https://orcid.org/0000-0003-0973-8645

Funding

Nanjing Drum Tower Hospital Academic Innovation Peak Project 2024-DF-03National Natural Science Fund 81970545National Natural Science Fund 82100286National Natural Science Fund 82170609National Natural Science Fund 82460123National Natural Science Fund 82570750Natural Science Foundation of Jiangsu Province BK20231118The Innovative Team of Yunnan Province 202305AS350019Yunnan Province Talent Cultivation Project YNWR-MY-2019-036Yunnan Provincial Key Research and Development Plan 202403AC100020Yunnan Provincial Natural Science Foundation 202201AY070001-042
6 · The paper itself

Abstract

Metabolic dysfunction-associated steatohepatitis (MASH) is a significant contributor to liver fibrosis due to hepatic stellate cells (HSCs) activation. The anti-apoptotic gene Nuclear Factor I-B (NFIB) has been implicated in regulating cell proliferation and differentiation in the context of liver injury. However, its role in HSCs differentiation remains unclear. Our study reveals NFIB as the most markedly down-regulated transcription factor during HSCs activation, as evidenced by single-cell sequencing analysis of liver fibrosis. Clinical examination of liver tissues from MASH fibrosis patients corroborated diminished NFIB expression in HSCs across varying fibrosis stages. Using a murine model of liver fibrosis induced by a choline-deficient, amino acid-restricted high-fat diet (CDAHFD) and carbon tetrachloride (CCl

Indexed as

Chemokine CCL5Liver CirrhosisNFI Transcription FactorsAnimalsCarbon TetrachlorideDisease Models, AnimalHepatic Stellate CellsHumansLiverMaleMiceMice, Inbred C57BLCarbon TetrachlorideChemokine CCL5NFI Transcription FactorsChemokine C─C motif ligand 5hepatic stellate cellsliver fibrosismetabolic dysfunction‐associated steatohepatitisnuclear factor I‐B

Identifiers

PMID41436407
PMCPMC12955860

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.