Evidence map›Paper›PMID 41436263›Full record

ArticleBMJ open2025

Randomised trial protocol to assess efficacy of modified olfactory training method for patients with postinfectious olfactory dysfunction.

Jiatong Xie, Yankun Li, Hong He, Yuxing Liu, Lina Chen, Xiaolu Liu, Danhua Zhao, Dawei Wu

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06829706 (A Randomized Trail Protocol to Access Efficacy of Modified Olfactory Training Method for Patients With Post-viral Olfactory Dysfunction), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06829706 narecruitingnot on this map

A Randomized Trail Protocol to Access Efficacy of Modified Olfactory Training Method for Patients With Post-viral Olfactory Dysfunction

TypeinterventionalSponsorPeking University Third HospitalRan2025 to 2027Enrolled150ConditionsOlfactory Dysfunction, Post Viral Olfactory Dysfunction (PVOD)ArmsConventional olfactory training device, Modified olfactory training device, Conventional olfactory training device with placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiatong Xie *Department of Otolaryngology, Peking University Third Hospital, Beijing, China.
Yankun Li *Department of Otolaryngology, Peking University Third Hospital, Beijing, China.
Hong He *Department of Otolaryngology, Yan'an Hospital of Traditional Chinese Medicine, Yanan, China.
Yuxing LiuDepartment of Otolaryngology, Peking University Third Hospital, Beijing, China.
Lina ChenDepartment of Otolaryngology, Peking University Third Hospital, Beijing, China.
Xiaolu LiuDepartment of Neurology, Peking University Third Hospital, Beijing, China.
Danhua ZhaoDepartment of Neurology, Peking University Sixth Hospital, Beijing, China.
Dawei WuDepartment of Otolaryngology, Peking University Third Hospital, Beijing, China davidwuorl@163.com.ORCID http://orcid.org/0000-0003-4888-3255

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis article outlines the research protocol for a multicentre, randomised, controlled study designed to evaluate the therapeutic effect of a modified olfactory training (MOT) based on bi-directional nasal drug delivery system for patients with postinfectious olfactory dysfunction (PIOD), and to compare its efficacy with conventional olfactory training (COT). METHODS AND ANALYSIS: This is a multicentre study in which patients will be recruited from several participating hospitals. Patients will be divided into three groups: COT group using COT device, MOT group using MOT device, Control group without any intervention other than follow-up. The olfactory training (OT) intervention will last for 12 months. The primary outcome will be the improvement in olfactory ability from baseline measurement to the end of intervention or control period, evaluated through the total Threshold, Discrimination, Identification (TDI) score of the Sniffin' Stick test. Secondary outcomes will be changes in olfactory bulb volume and shape, olfactory-related brain area volume, olfactory and trigeminal nerve-related potentials, and subjective assessments. ETHICS AND DISSEMINATION: This study protocol has been registered with ClinicalTrials.gov. The Peking University Third Hospital Medical Science Research Ethics Committee reviewed and approved this study protocol. The results will be published in BMJ Open. TRIAL REGISTRATION NUMBER: NCT06829706.

Indexed as

Olfaction DisordersSmellAdministration, IntranasalAdultFemaleHumansMaleMiddle AgedMulticenter Studies as TopicOlfactory BulbOlfactory TrainingRandomized Controlled Trials as TopicTreatment OutcomeAdult otolaryngologyClinical ProtocolsNEUROPHYSIOLOGY

Identifiers

PMID41436263
PMCPMC12730742

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.