Instrumental learning enhances the intrinsic excitability of basal amygdala projection neurons.

Eddie T Wise, Philip Jean-Richard-Dit-Bressel, Joanna O-Y Yau, Gavan P McNally, John M Power

Abstract read

In one paragraph

Article in Learning & memory (Cold Spring Harbor, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eddie T WiseTranslational Neuroscience Facility and Department of Physiology, School of Biomedical Sciences, UNSW Sydney, Sydney NSW 2052, Australia.

Philip Jean-Richard-Dit-BresselSchool of Psychology, UNSW Sydney, Sydney NSW 2052, Australia.ORCID http://orcid.org/0000-0002-0898-8987

Joanna O-Y YauSchool of Psychology, UNSW Sydney, Sydney NSW 2052, Australia.ORCID http://orcid.org/0000-0003-2235-5956

Gavan P McNallySchool of Psychology, UNSW Sydney, Sydney NSW 2052, Australia.ORCID http://orcid.org/0000-0001-9061-6463

John M PowerTranslational Neuroscience Facility and Department of Physiology, School of Biomedical Sciences, UNSW Sydney, Sydney NSW 2052, Australia john.power@unsw.edu.au.ORCID http://orcid.org/0000-0002-2478-8416

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The basolateral amygdala (BLA) is critical for Pavlovian and instrumental emotional association learning. Pavlovian fear conditioning is accompanied by increased excitability of BLA neurons. Here we tested whether instrumental learning similarly enhances BLA excitability. Electrophysiological recordings were taken from BLA neurons in brain slices prepared from instrumentally trained Long-Evans rats. Both reward and punishment training increased intrinsic excitability. Moreover, excitability positively correlated with performance on the punishment task, suggesting a functional link between neuronal excitability and learning. These findings support the idea that enhanced excitability facilitates synaptic plasticity and circuit integration during instrumental learning.

Indexed as

AmygdalaBasolateral Nuclear ComplexConditioning, OperantNeuronsAction PotentialsAnimalsMalePunishmentRatsRats, Long-EvansReward

Identifiers

PMID41436250

DOI10.1101/lm.054161.125

PMCPMC12735317

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.