ArticleThe Journal of clinical endocrinology and metabolism2026
Impact of Parathyroidectomy on Vascular Stiffness: Exploring Pulse Wave Velocity and Renal Resistive Index.
Article in The Journal of clinical endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Impact of Parathyroidectomy on Vascular Stiffness: Exploring Pulse Wave Velocity and Renal Resistive Index.The Journal of clinical endocrinology and metabolism · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
contextPrimary hyperparathyroidism (PHPT), characterized by elevated parathyroid hormone (PTH) and hypercalcemia, has been implicated in vascular calcification and increased arterial stiffness. Carotid-femoral pulse wave velocity (PWV) is the gold-standard marker of large artery stiffness, while the Augmentation Index (AI), pulse pressure (PP), and Renal Resistive Index (RRI) offer insights into wave reflection and microvascular function.
objectiveThis study aimed to assess the associations between PTH levels and these vascular parameters before and after parathyroidectomy (PTX).
methodsIn a prospective, monocentric cohort study, PHPT patients undergoing elective PTX had vascular assessments at baseline and 6 months postoperatively. Associations between PTH and vascular markers (PWV, AI, PP, and RRI) were evaluated using Pearson correlations, linear regression, and multivariable mixed-effects regression models adjusted for cardiovascular and metabolic covariates.
resultsAmong 107 patients (80% women, median age 64 years), PTH and PWV significantly declined 6 months after PTX, whereas AI, PP, and RRI remained unchanged. In adjusted models, higher PTH was independently associated with increased PWV (β = .10; 95% CI, 0.02-0.18). No statistically significant associations were observed between PTH and AI or PP. At baseline, PTH levels were positively associated with RRI (β = 2.16; 95% CI, 0.19-4.13), but this association did not persist after PTX.
conclusionElevated PTH is independently associated with greater large artery stiffness in PHPT, and this effect appears to be at least partially reversible following PTX. However, changes in PTH were not associated with short-term changes in renal microvascular resistance, suggesting a delayed or less reversible effect on renal vasculature.
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