Evidence map›Paper›PMID 41435373›Full record

Trial reportJournal of medical Internet research2025

Adherence to Accelerometer Use in Older Adults Undergoing mHealth Cardiac Rehabilitation: Secondary Analysis of a Randomized Clinical Trial.

Souptik Barua, Dhairya Upadhyay, Stephanie Pena, Riley McConnell, Ashwini Varghese, Samrachana Adhikari, Erik LeRoy, Antoinette Schoenthaler, John A Dodson

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of medical Internet research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03978130 (REhabilitation at Home uSIng mobiLe Health In oldEr Adults After hospitalizatioN for Ischemic hearT Disease), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03978130 nacompletednot on this map

REhabilitation at Home uSIng mobiLe Health In oldEr Adults After hospitalizatioN for Ischemic hearT Disease

TypeinterventionalSponsorNYU Langone HealthRan2020 to 2024Enrolled400ConditionsIschemic Heart DiseaseArmsmHealth-CR
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Souptik BaruaDivision of Precision Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, United States.ORCID https://orcid.org/0000-0002-1675-8874
Dhairya UpadhyayDivision of Precision Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, United States.ORCID https://orcid.org/0009-0009-3044-4335
Stephanie PenaLeon H Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, United States.ORCID https://orcid.org/0009-0001-8690-4582
Riley McConnellLeon H Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, United States.ORCID https://orcid.org/0009-0008-3213-5459
Ashwini VargheseLeon H Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, United States.ORCID https://orcid.org/0009-0007-1155-5190
Samrachana AdhikariDepartment of Population Health, New York University Grossman School of Medicine, New York, NY, United States.ORCID https://orcid.org/0000-0001-9954-5999
Erik LeRoyRusk Department of Rehabilitation Medicine, New York University Grossman School of Medicine, New York, NY, United States.ORCID https://orcid.org/0009-0007-6845-0429
Antoinette SchoenthalerDepartment of Population Health, New York University Grossman School of Medicine, New York, NY, United States.ORCID https://orcid.org/0000-0003-4905-5136
John A DodsonLeon H Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, United States.ORCID https://orcid.org/0000-0003-0163-3013

Funding

Rehabilitation at home using mobile health in older adults after hospitalization for ischemic heart disease (RESILIENT)R01AG062520 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DODSON, JOHN A · 2019 to 2023
$3.3M
Midcareer award in aging-related subspecialty researchK24AG080025 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI John A Dodson · 2023 to 2026
$495k
American Heart Association-American Stroke Association 24SCEFIA1252353NIA NIH HHS K24 AG080025NIA NIH HHS R01 AG062520
6 · The paper itself

Abstract

backgroundWearable accelerometers, which continuously record physical activity metrics, are commonly used in mobile health-enabled cardiac rehabilitation (mHealth-CR). The association between adherence to accelerometer use during mHealth-CR and improvement in clinical outcomes, such as functional capacity, is understudied. The emergence of artificial intelligence (AI) technology provides novel opportunities to investigate accelerometry use patterns in relation to mHealth-CR outcomes.

objectiveIn this study, we sought to use an AI clustering framework to identify distinct behavioral phenotypes of adherence to accelerometer use. We then aimed to quantify the association of these adherence phenotypes with functional capacity improvements in older adults undergoing mHealth-CR.

methodsWe analyzed data from the RESILIENT (Rehabilitation at Home Using Mobile Health in Older Adults After Hospitalization for Ischemic Heart Disease) trial, the largest randomized clinical study to date comparing mHealth-CR versus usual care in older adults (aged ≥65 years). Intervention arm participants were instructed to wear a Fitbit accelerometer for the 3-month study duration. Adherence to accelerometer use was quantified as overall adherence (percentage of days worn) via k-means clustering AI-derived measures and compared with changes in 6-minute walk distance (6-MWD), adjusted for demographic and clinical covariates.

resultsAmong 271 participants with a mean age of 71 years (SD 8), of whom 198 (73%) were male, accelerometers were worn for an average of 76 days (95% confidence limits 73,78) over 3 months. Adjusted analyses showed a weak association between days of wear and improvement in 6-MWD, with every 30 additional days associated with an 11-meter improvement (P=.08). Our k-means clustering framework identified adherence phenotypes at two resolutions: low resolution (k=2 clusters) and high resolution (k=8 clusters). The consistently high adherence cluster trended toward a 24.6-meter improvement in 6-MWD compared to the low and declining adherence clusters (n=39; 95% CI 0.7-49.9; P=.06). The 8-cluster phenotyping revealed a richer set of adherence patterns, with the consistently high adherence cluster in this analysis having a 38.5-meter (95% CI 2.2-74.7; P=.04) improvement in 6-MWD than the low adherence cluster, as well as greater average daily steps over the 3-month intervention (mean 7518, SD 3415 vs mean 4800, SD 2920 steps; P=.008).

conclusionsA time-series AI clustering framework identified a range of behavioral phenotypes representing different degrees of adherence to accelerometer use. Regression analysis identified a weak association between the higher adherence phenotype and functional capacity improvement in older adults undergoing mHealth-CR. Our AI-derived accelerometry adherence phenotypes may offer a new approach to tailor mHealth-CR regimens to individual patients, potentially leading to better outcomes in this high-risk population.

trial registrationClinicalTrials.gov NCT03978130; https://clinicaltrials.gov/study/NCT03978130. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.2196/32163.

Indexed as

AccelerometryCardiac RehabilitationPatient ComplianceTelemedicineAgedAged, 80 and overArtificial IntelligenceExerciseFemaleHumansMaleWearable Electronic DevicesaccelerometryAIartificial intelligencecardiac rehabilitationFitbitmHealthmobile healthphenotypingphysical activitywearable

Identifiers

PMID41435373
PMCPMC12777647

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.