Evidence map›Paper›PMID 41433963›Full record

ArticleACS synthetic biology2026

Heterologous Expression and CRISPR/Cas9-Assisted Manipulation of the Hybrid Gene Cluster Specifying the Biosynthesis of Meroterpenoids and Phenazines.

Olha Schneider, Martin Zehl, Margherita Miele, Vittorio Pace, Corinna Brungs, Jan-Fang Cheng, Scarlet Hummelbrunner, Verena M Dirsch, Sergey B Zotchev

Abstract read
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In one paragraph

Article in ACS synthetic biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Olha SchneiderDepartment of Pharmaceutical Sciences, Division of Pharmacognosy, University of Vienna, Vienna 1090, Austria.
Martin ZehlDepartment of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Vienna 1090, Austria.ORCID 0000-0001-9685-0373
Margherita MieleDepartment of Chemistry, University of Turin, Via P. Giuria 7, Turin 10125, Italy.
Vittorio PaceDepartment of Chemistry, University of Rome "La Sapienza", P.le A. Moro, 5, Rome 00185, Italy.
Corinna BrungsDepartment of Pharmaceutical Sciences, Division of Pharmacognosy, University of Vienna, Vienna 1090, Austria.
Jan-Fang ChengUS Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0001-7315-7613
Scarlet HummelbrunnerDepartment of Pharmaceutical Sciences, Division of Pharmacognosy, University of Vienna, Vienna 1090, Austria.
Verena M DirschDepartment of Pharmaceutical Sciences, Division of Pharmacognosy, University of Vienna, Vienna 1090, Austria.ORCID 0000-0002-9261-5293
Sergey B ZotchevDepartment of Pharmaceutical Sciences, Division of Pharmacognosy, University of Vienna, Vienna 1090, Austria.ORCID 0000-0002-9324-245X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A hybrid gene cluster,

Indexed as

TerpenesAnti-Bacterial AgentsCRISPR-Cas SystemsPhenazinesStreptomycesAnti-Bacterial AgentsPhenazinesTerpenesactivationCRISPR/Cas9heterologous expressionhybrid meroterpenoids/phenazines biosynthetic gene clustermarfuraquinocinsStreptomyces

Identifiers

PMID41433963
PMCPMC12814520

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.