ArticleMicrobiology spectrum2026
Efficacy of cefiderocol in murine models of ventilator-associated pneumonia caused by carbapenem-resistant non-fermenting Gram-negative bacilli, with pharmacokinetic evaluation.
Kenji Ota, Norihito Kaku, Fujiko Mitsumoto-Kaseida, Naoki Uno, Kosuke Kosai, Takahiro Takazono, Hiroo Hasegawa, Kei Sakamoto, Yoshitomo Morinaga, Koichi Izumikawa and 3 more
Abstract read
In one paragraphArticle in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Kenji OtaDepartment of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.ORCID 0000-0001-7180-0820 Norihito KakuDepartment of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.ORCID 0000-0002-4086-4853 Fujiko Mitsumoto-KaseidaDepartment of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Naoki UnoDepartment of Medical Virology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Kosuke KosaiDepartment of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.ORCID 0009-0009-2296-6539 Takahiro TakazonoDepartment of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.ORCID 0000-0002-0696-5386 Hiroo HasegawaDepartment of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Kei SakamotoDepartment of Microbiology and Immunology, Graduate School of Medicine, Yamaguchi University, Yamaguchi, Japan.
Yoshitomo MorinagaDepartment of Microbiology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.ORCID 0000-0002-3827-6411 Koichi IzumikawaDepartment of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Hiroshi MukaeDepartment of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Hiroshige MikamoDepartment of Clinical Infectious Diseases, Aichi Medical University Graduate School of Medicine, Aichi, Japan.ORCID 0000-0001-8876-6411 Katsunori YanagiharaDepartment of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Funding
Shionogi
6 · The paper itselfAbstract
Ventilator-associated pneumonia (VAP) caused by carbapenem-resistant non-fermenting Gram-negative bacilli poses a serious clinical challenge due to limited treatment options. Cefiderocol (CFDC) is a novel cephalosporin with a catechol moiety that mimics siderophore function, enabling targeted antimicrobial activity against these pathogens. We evaluated the
Indexed as
Anti-Bacterial AgentsCephalosporinsPneumonia, Ventilator-AssociatedAcinetobacter baumanniiAcinetobacter InfectionsAnimalsCarbapenemsCefiderocolDisease Models, AnimalFemaleGram-Negative BacteriaMiceMicrobial Sensitivity TestsPseudomonas aeruginosaPseudomonas InfectionsAnti-Bacterial AgentsCarbapenemsCefiderocolCephalosporinsAcinetobacter baumanniicefiderocolmouse modelpharmacokineticsPseudomonas aeruginosaventilator-associated pneumonia
Identifiers
PMID41433406
PMCPMC12889036
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