Evidence map›Paper›PMID 41433402›Full record

ArticleAntimicrobial agents and chemotherapy2026

A short antimicrobial peptides family demonstrates efficacy to infection via a multimodal mechanism of action.

Yifan Liu, Pengfei Cui, Jingyi Sun, Shaoguo Ru

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yifan LiuLab of Environmental Health and Ecological Engineering, College of Marine Life Science, Ocean University of China, , Qingdao, China.ORCID 0000-0001-7722-4369
Pengfei CuiLab of Environmental Health and Ecological Engineering, College of Marine Life Science, Ocean University of China, , Qingdao, China.ORCID 0000-0002-9621-4403
Jingyi SunNorth China Sea Marine Forecasting Center of State Oceanic Administration, Qingdao, China.
Shaoguo RuLab of Environmental Health and Ecological Engineering, College of Marine Life Science, Ocean University of China, , Qingdao, China.

Funding

Pengfei Cui 31902421
6 · The paper itself

Abstract

The escalating threat posed by multidrug-resistant (MDR) Gram-negative "superbugs" has intensified. Short antimicrobial peptides (SAMPs) have emerged as promising therapeutics with sustained potency and cost-effectiveness against drug-resistant infections. Here, we report a family of 15-residue SAMPs derived through modifying related amino acids of Kassporin-KS1 (FA), utilizing database-filtering technology to identify the most probable structural parameters related to Gram-negative bacteria. Most SAMPs exhibit sub-μM antimicrobial activity with reliable stability and low toxicity. Notably, KR and RK demonstrate significant efficacy in combating biofilms and sepsis infections

Indexed as

Anti-Bacterial AgentsAntimicrobial PeptidesGram-Negative BacteriaAnimalsBiofilmsDrug Resistance, Multiple, BacterialHumansMiceMicrobial Sensitivity TestsSepsisAnti-Bacterial AgentsAntimicrobial Peptidesdatabase-filtering technologymultidrug-resistant (MDR)multimodal antimicrobial mechanismsepsis infectionsshort antimicrobial peptides (SAMPs)

Identifiers

PMID41433402
PMCPMC12888869

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.