Evidence map›Paper›PMID 41433200›Full record

ArticleeLife2025

A single-cell atlas of the testicular interstitium defines Leydig progenitor networks sustaining Leydig cell homeostasis across the lifespan.

Xiaojia Huang, Kai Xia, Meiling Yang, Mengzhi Hong, Meihua Jiang, Weiqiang Li, Zhenmin Lei, Andy Peng Xiang, Wei Zhao

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaojia Huang *Department of Sports Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.ORCID https://orcid.org/0009-0005-1477-1644
Kai Xia *Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, China.
Meiling Yang *Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Mengzhi HongDepartment of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Meihua JiangCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, China.
Weiqiang LiCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, China.
Zhenmin LeiDepartment of OB/GYN and Women's Health, University of Louisville School of Medicine, Louisville, United States.
Andy Peng XiangCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, China.ORCID https://orcid.org/0000-0003-3409-5012
Wei ZhaoCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, China.ORCID https://orcid.org/0000-0002-0774-2571

Funding

High-level Hospital Construction Project of Guangdong Provincial People's Hospital DFJHBF202102National Key Research and Development Program of China 2017YFA0103800National Key Research and Development Program of China 2023YFC2506100National Natural Science Foundation of China 82172698National Natural Science Foundation of China 82303201
6 · The paper itself

Abstract

Declining rates of male fertility pose a significant clinical challenge, while the mechanisms underlying testicular interstitial function remain incompletely understood. Here, we conducted a comprehensive analysis of the single-cell transcriptomic landscape of the murine testicular interstitium across the postnatal lifespan. The investigation unveiled a previously unrecognized population of Cd34

Indexed as

HomeostasisLeydig CellsLongevityStem CellsTestisAgingAnimalsCell DifferentiationMaleMesenchymal Stem CellsMiceMice, Inbred C57BLSingle-Cell Analysiscell biologyglutathione metabolismLeydig cellmesenchymal cellsmousesingle-cell transcriptomicstesticular interstitium

Identifiers

PMID41433200
PMCPMC12826670

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.