ArticleAnnals of medicine2026
Hemispheric imbalance in mild cognitive impairment: a graph-theoretical analysis of multimodal brain networks.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Response to letter regarding "hemispheric imbalance in mild cognitive impairment: a graph-theoretical analysis of multimodal brain networks".Annals of medicine · 2026Article
- Comment on 'Hemispheric imbalance in mild cognitive impairment: a graph-theoretical analysis of multimodal brain networks'.Annals of medicine · 2026Article
- Electroencephalography Functional Network Responses to Immersive Virtual Reality in Alzheimer Disease and Mild Cognitive Impairment: Exploratory Single-Session 3-Group Repeated-Measures Study.JMIR serious games · 2026Article
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Authors and funding
9 authors.
Funding
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Abstract
backgroundHemispheric lateralization of brain structure and function supports cognitive processing. However, its alterations across different cognitive impairment subtypes and severities remain unclear.
methodsIn this case-control study, 104 participants were enrolled, including 47 with amnestic mild cognitive impairment (aMCI), 27 with non-amnestic MCI (naMCI), and 30 healthy controls. Functional and white matter structural brain networks were constructed separately for the left and right hemispheres. Graph-theoretical metrics and structure-function coupling were computed to assess intergroup and interhemispheric differences. Correlation analyses examined associations between network alterations and cognitive performance.
resultsFunctionally, both MCI groups showed a significant leftward reduction in small-world properties (
conclusionsaMCI and naMCI exhibit distinct patterns of lateralization abnormalities, with aMCI patients being characterized by the disintegration of specific local functional networks in the left hemisphere. Therefore, ameliorating abnormal patterns of hemispheric lateralization could serve as a purpose of the intervention.
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