Evidence map›Paper›PMID 41433073›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

A SynB1-conjugated antibody cocktail crosses the blood-brain barrier to produce a therapeutic effect on rabies.

Zeheng Ren, Caiqian Wang, Haoran Wang, Qiong Wu, Qingxiu Hou, Xue Qi, Wenna He, Xiaoyu Zhang, Jiawu Wan, Zhen F Fu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zeheng Ren *National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.
Caiqian Wang *National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.
Haoran WangNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.
Qiong WuNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.
Qingxiu HouNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.
Xue QiNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.
Wenna HeNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.
Xiaoyu ZhangNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.
Jiawu WanNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.
Zhen F FuNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0000-0001-6293-9329
Ming ZhouNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0000-0001-7012-017X
Ling ZhaoNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0000-0003-0569-8105

Funding

MOE | Fundamental Research Funds for the Central Universities (Fundamental Research Fund for the Central Universities) 2662025DKPY009MOST | National Key Research and Development Program of China (NKPs) No. 2022YFD1800100
6 · The paper itself

Abstract

Rabies, caused by the neurotropic

Indexed as

Antibodies, NeutralizingAntibodies, ViralBlood-Brain BarrierRabiesRabies virusAnimalsCell-Penetrating PeptidesCombined Antibody TherapeuticsFemaleHumansMiceAntibodies, NeutralizingAntibodies, ViralCell-Penetrating PeptidesCombined Antibody Therapeuticsantibody cocktail treatmentblood–brain barrier penetrationCNS deliveryrabies therapySynB1 peptide

Identifiers

PMID41433073
PMCPMC12772202

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.