Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Gongwen Chen *State Key Laboratory of Genetics and Development of Complex Phenotypes, Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Microbiology and Immunology, School of Life Sciences, Fudan University, Shanghai 200438, P.R. China.ORCID 0000-0001-5876-9902
Ji Hyung Jun *Children's Medical Center Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-2563-4144
Tobias WijshakeChildren's Medical Center Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-1784-2100
Edward O KwartengChildren's Medical Center Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0001-6880-1363
Yunyang LiState Key Laboratory of Genetics and Development of Complex Phenotypes, Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Microbiology and Immunology, School of Life Sciences, Fudan University, Shanghai 200438, P.R. China.ORCID 0009-0003-9969-1031
Minwei YuanState Key Laboratory of Genetics and Development of Complex Phenotypes, Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Microbiology and Immunology, School of Life Sciences, Fudan University, Shanghai 200438, P.R. China.
Joseph RoseChildren's Medical Center Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Shan LiState Key Laboratory of Genetics and Development of Complex Phenotypes, Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Microbiology and Immunology, School of Life Sciences, Fudan University, Shanghai 200438, P.R. China.
Sarah CobbDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0001-8725-4588
Willow SerpaDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0009-0004-0510-560X
Brayden FolgerDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0009-0008-2858-7591
Yafeng LiChildren's Medical Center Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-1024-6990
Li LiJerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Dallas, TX 75235.ORCID 0000-0003-2064-2177
Weina ChenDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0001-5638-4371
James J CollinsDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0001-5237-1004
Jipeng WangState Key Laboratory of Genetics and Development of Complex Phenotypes, Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Microbiology and Immunology, School of Life Sciences, Fudan University, Shanghai 200438, P.R. China.ORCID 0000-0003-0107-424X
Michalis AgathocleousChildren's Medical Center Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-3427-1023
Funding
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4M
The Biology of Stem Cells in the Human Parasite Schistosoma MansoniR01AI121037 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI COLLINS, JAMES J · 2016 to 2025
$4.4M
Characterizing sexual development of the human parasite Schistosoma mansoniR01AI150776 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI COLLINS, JAMES J · 2020 to 2024
$2.7M
The role of ascorbate in myelopoiesis and infectionR01DK125713 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI AGATHOCLEOUS, MICHALIS · 2021 to 2025
$1.8M
The role of glycolysis and glucose oxidation in hematopoiesisR01HL161387 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI AGATHOCLEOUS, MICHALIS · 2022 to 2025
$1.6M
American Society of Hematology (ASH) Scholar AwardCancer Prevention and Research Institute of Texas (CPRIT) RP210209Cancer Prevention and Research Institute of Texas (CPRIT) RR180007Fudan University (FDU) 24FCA04HHS | NIH (NIH) R01AI121037HHS | NIH (NIH) R01AI150776HHS | NIH (NIH) R01DK125713HHS | NIH (NIH) R01HL161387Moody Foundation (Moody) N/AMOST | National Key Research and Development Program of China (NKPs) 2021YFC2300800NHLBI NIH HHS R01 HL161387NIAID NIH HHS R01 AI150776NIDDK NIH HHS P30 DK127984NIDDK NIH HHS R01 DK125713Welch Foundation (The Welch Foundation) I-1948-20180324Welch Foundation (The Welch Foundation) I-2053-20210327
6 · The paper itself
Abstract
The ability to synthesize essential molecules is sometimes lost in evolution. A classic example is ascorbate (vitamin C), which is synthesized in most animals by L-gulonolactone oxidase (GULO), an enzyme lost multiple independent times in animal evolution. This event is thought to be evolutionarily neutral; however,
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Loss of vitamin C biosynthesis protects from the pathology of a parasitic infection. · full record | OpenQuestion