Evidence map›Paper›PMID 41433018›Full record

ArticleGeroScience2026

Is grip strength a marker for cognitive function, neurodegeneration, and resilience?

Alexander Ivan B Posis, Hilary L Colbeth, Mihika S Deshpande, Kristen M George, Batool Rizvi, Rifat B Alam, Ruijia Chen, Dan M Mungas, Paola Gilsanz, María M Corrada and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alexander Ivan B PosisDepartment of Public Health Sciences, University of California, Davis, Medical Sciences 1-C, One Shield's Ave, Davis, CA, 95616, USA. abposis@health.ucdavis.edu.ORCID http://orcid.org/0000-0002-7317-0444
Hilary L ColbethDepartment of Public Health Sciences, University of California, Davis, Medical Sciences 1-C, One Shield's Ave, Davis, CA, 95616, USA.
Mihika S DeshpandeDepartment of Public Health Sciences, University of California, Davis, Medical Sciences 1-C, One Shield's Ave, Davis, CA, 95616, USA.
Kristen M GeorgeDepartment of Public Health Sciences, University of California, Davis, Medical Sciences 1-C, One Shield's Ave, Davis, CA, 95616, USA.
Batool RizviDepartment of Public Health Sciences, University of California, Davis, Medical Sciences 1-C, One Shield's Ave, Davis, CA, 95616, USA.
Rifat B AlamDepartment of Public Health Sciences, University of California, Davis, Medical Sciences 1-C, One Shield's Ave, Davis, CA, 95616, USA.
Ruijia ChenDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Dan M MungasDepartment of Neurology, University of California, Davis, Davis, CA, USA.
Paola GilsanzKaiser Permanente Northern California Division of Research, Pleasanton, CA, USA.
María M CorradaDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
Rachel A WhitmerDepartment of Public Health Sciences, University of California, Davis, Medical Sciences 1-C, One Shield's Ave, Davis, CA, 95616, USA.

Funding

Epidemiology of Age-related Dementia, Mild Cognitive Impairment and Brain Pathology in Cohort of Oldest-OldR01AG056519 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Maria Corrada, Paola Gilsanz · 2022 to 2026
$25.8M
UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI OANH L MEYER · 2021 to 2026
$25.2M
Study of Healthy Aging in African AmericansR01AG050782 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Paola Gilsanz, Rachel A Whitmer · 2023 to 2026
$19.1M
Lifecourse health, cerebral pathology and ethnic disparities in dementia (KHANDLE Study)R01AG052132 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GILSANZ, PAOLA, GLYMOUR, MEDELLENA MARIA · 2021 to 2025
$18.0M
Bridging Social Epidemiology and Policy for ADRD Prevention: Effects of Poverty Alleviation Policies on Alzheimer's Disease and Related Dementias Risk and DisparitiesK99AG088369 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Ruijia Chen · 2025 to 2026
$264k
NIA NIH HHS K99 AG088369NIA NIH HHS P30 AG072972NIA NIH HHS R01 AG050782NIA NIH HHS R01 AG052132NIA NIH HHS R01 AG056519
6 · The paper itself

Abstract

Assessing whether grip strength is associated with cognitive decline and brain health could help identify a target to prevent or delay cognitive impairment. Therefore, we tested whether grip strength is associated with brain health as indicated by magnetic resonance imaging and domain specific cognitive decline. We also assessed whether grip strength was a cognitive resilience proxy using moderation tests. This study included cognitive and neuroimaging data from 861 participants in three harmonized cohorts. We fit multivariable linear mixed-effects and linear regression models to test associations between grip strength, neuroimaging markers, and cognition. We also tested moderation by gender and age. Greater grip strength was associated with slower verbal episodic memory decline and greater total gray matter volume. Associations of grip strength with executive function, total hippocampal volume, and white matter hyperintensities were not significant, but in the expected direction. Age moderated associations of grip strength and white matter hyperintensities. Grip strength was a significant proxy for cognitive resilience related to white matter hyperintensity volume and verbal episodic memory decline only. Future research should examine other measures of physical performance that are associated with later-life cognitive and brain health.

Indexed as

CognitionCognitive DysfunctionHand StrengthAgedAged, 80 and overFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsCognitive declineNeuroimagingPhysical functionPhysical performance

Identifiers

PMID41433018
PMCPMC13601401

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.