ArticleAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2026
Numerical simulation of microfluidic droplet shooter for generation of femtoliter-picoliter droplets in gas phase.
Article in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A comprehensive understanding of fluid behavior in microchannels is crucial for the precise generation of liquid droplets, which has become increasingly important with the development of microfluidic technologies. Our group has previously developed a microfluidic droplet shooter that generates fL–pL liquid droplets utilizing two-step gas/liquid flow focusing. However, due to the complicated channel geometry of the droplet shooter, the fabrication process is complicated, and the characterization of these systems remains inadequate. The present study focuses on the computational modeling of liquid droplet generation using a microfluidic droplet shooter that utilizes gas-liquid two-phase flow. A computational model is established to delineate the complex flow within the shooter. Additionally, we reveal the characteristics of liquid droplet generation in the gas phase. We further investigate the design optimization of the microfluidic droplet shooter for generating fL–pL liquid droplets. We propose and analyze several designs, such as optimizing the angles of the gas channels and the length of the liquid column. Faithful to the dimensions and physics of a particular microfluidic droplet shooter, the simulations provide precise predictions in droplet formation. By systematically analyzing the effects of geometric configurations, this research provides valuable design guidance to improve the performance of devices used in areas such as biotechnology, analytical chemistry, and life sciences.
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