Evidence map›Paper›PMID 41432955›Full record

ArticlePflugers Archiv : European journal of physiology2025

Modulation of cardiac contractility and redox balance via cannabinoid type II receptor activation in healthy rats.

Suzana Luisa Alves Fernandes, Yan Costa Gonçalves, Francisco Tadeu Rantin, Ana Lúcia Kalinin, José Wilson Magalhães Bassani, Rosana Almada Bassani, Guilherme Borges Pereira, Diana Amaral Monteiro

Abstract read
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Article in Pflugers Archiv : European journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Suzana Luisa Alves FernandesDepartment of Physiological Sciences, Federal University of São Carlos (UFSCar), São Carlos, São Paulo, 13565- 905, Brazil.
Yan Costa GonçalvesDepartment of Physiological Sciences, Federal University of São Carlos (UFSCar), São Carlos, São Paulo, 13565- 905, Brazil.
Francisco Tadeu RantinDepartment of Physiological Sciences, Federal University of São Carlos (UFSCar), São Carlos, São Paulo, 13565- 905, Brazil.
Ana Lúcia KalininDepartment of Physiological Sciences, Federal University of São Carlos (UFSCar), São Carlos, São Paulo, 13565- 905, Brazil.
José Wilson Magalhães BassaniDepartment of Biomedical Engineering, School of Electrical and Computing Engineering, University of Campinas (Unicamp), Campinas, São Paulo, 13083-881, Brazil.
Rosana Almada BassaniDepartment of Biomedical Engineering, School of Electrical and Computing Engineering, University of Campinas (Unicamp), Campinas, São Paulo, 13083-881, Brazil.
Guilherme Borges PereiraDepartment of Physiological Sciences, Federal University of São Carlos (UFSCar), São Carlos, São Paulo, 13565- 905, Brazil.
Diana Amaral MonteiroDepartment of Physiological Sciences, Federal University of São Carlos (UFSCar), São Carlos, São Paulo, 13565- 905, Brazil. dianamonteiro@ufscar.br.ORCID 0000-0002-1178-6673

Funding

Conselho Nacional das Fundações Estaduais de Amparo à Pesquisa CNPq, grant no. 130995/2022-3Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPq, grant no. 301809/2022-4Ministério da Saúde FINEP grant no. 01-13-0214-00
6 · The paper itself

Abstract

The activation of cannabinoid receptor type II (CB2r) has been demonstrated to provide cardioprotective benefits against heart diseases. Nevertheless, the physiological effects of CB2r activation in healthy myocardial tissue remain poorly understood. Given the current gap in knowledge, particularly relevant in light of the growing therapeutic use of cannabinoids, this study aimed to investigate the effects of a single intraperitoneal injection of the selective synthetic CB2r agonist HU-308 on ventricular contractility, the expression of Ca

Indexed as

Myocardial ContractionReceptor, Cannabinoid, CB2AnimalsCalcium-Binding ProteinsCannabinoid Receptor AgonistsCyclic AMPGlutathioneMaleMyocardiumOxidation-ReductionOxidative StressRatsRats, WistarSarcoplasmic Reticulum Calcium-Transporting ATPasesCalcium-Binding ProteinsCannabinoid Receptor AgonistsCyclic AMPGlutathioneReceptor, Cannabinoid, CB2Sarcoplasmic Reticulum Calcium-Transporting ATPasesAntioxidant defense systemCa2+-handling protein expressionCannabinoid agonistCardiac functionMammalsOxidative stress

Identifiers

PMID41432955

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.