Evidence map›Paper›PMID 41432911›Full record

ReviewCellular and molecular life sciences : CMLS2025

The functional roles and mechanisms of polyamines in age-related bone diseases.

Jiaqiang Zhang, Chang Cai, Yifan Zhang, Cheng Luo, Shicheng Huo, Kun Wang, Changgui Shi, Jia Liu, Guohua Xu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiaqiang ZhangDepartment of Orthopedic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Chang CaiDepartment of Orthopedic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Yifan ZhangDepartment of Orthopedic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Cheng LuoDepartment of Orthopedics, The Third Affiliated Hospital of Naval Medical University, Shanghai, 201805, China.
Shicheng HuoDepartment of Orthopedic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Kun WangDepartment of Orthopedic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Changgui ShiDepartment of Orthopedic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China. charlieshi@smmu.edu.cn.
Jia LiuDepartment of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, 400042, China. 13506191593@163.com.
Guohua XuDepartment of Orthopedic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China. xuguohuamail@163.com.ORCID http://orcid.org/0000-0001-6743-1698

Funding

National Natural Science Foundation of China 81972076National Natural Science Foundation of China 82272533
6 · The paper itself

Abstract

Age-related bone diseases such as osteoporosis, osteoarthritis, and sarcopenia present complex pathogenesis. These conditions are associated with high morbidity, disability, and mortality rates, underscoring the urgent need for effective prevention and treatment strategies. Polyamines, a group of small-molecule compounds, regulate critical biological processes, including cell proliferation, differentiation, and apoptosis, and show potential bone-protective effects. Following the elucidation of polyamines’ therapeutic effects in cancer and neurodegenerative diseases, growing research attention has been directed toward their role in age-related bone disorders. This review synthesizes the current understanding of polyamines’ mechanisms in age-related bone diseases, analyzing their biological functions and bone-protective effects to explore the therapeutic potential for these conditions, thereby offering valuable perspectives to guide future investigations and clinical applications in this emerging field.

Indexed as

AgingBone DiseasesOsteoarthritisOsteoporosisPolyaminesSarcopeniaAnimalsBone and BonesHumansPolyaminesBone diseaseBone metabolismOsteoarthritisOsteoporosisPolyamineSarcopeniaSpermidineSpermine

Identifiers

PMID41432911
PMCPMC12799833

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.