ArticleIrish journal of medical science2026
Evaluation of optimal postnatal timing for the screening of neonatal hearing via transient evoked oto-acoustic emission (TEOAE): a retrospective cross-sectional study.
Article in Irish journal of medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundEarly detection of neonatal hearing loss is essential to prevent speech and developmental delays. The timing of testing can affect accuracy and false-positive rates, with limited data available from Pakistan.
aimsThis study aimed to evaluate the optimal postnatal timing for neonatal hearing screening via TEOAE in Karachi, Pakistan. MATERIALS AND
methodsThis cross-sectional study (January 2020–December 2024) included 5,143 neonates screened with TEOAE at two hospitals in Karachi. Both healthy newborns and NICU admissions were enrolled, excluding those with congenital ear malformations or incomplete records. Screening was performed on Day 3, 7, or 21; abnormal results were retested. Data were analyzed in SPSS v26.0 using Chi-square and Fisher’s exact tests (p < 0.05).
resultsOf 5,143 neonates screened, 4,915 (95.6%) passed, 206 (4.0%) required retesting, and 26 (0.5%) for confirmatory BERA. Day 7 yielded the highest diagnostic accuracy, with 1,675 of 1,714 (97.7%) passing and only 39 (2.3%) abnormal results, compared to 1,555 of 1,715 (90.7%) passing on Day 3 and 1,615 of 1,714 (94.2%) passing on Day 21. The differences were statistically significant (χ2 = 76.5, p < 0.001). Year-wise analysis also demonstrated progressive improvement in pass rates and reduction in referrals across the study period.
conclusionScreening at Day 7 postnatally provides the optimal balance of sensitivity and specificity for neonatal hearing screening via TEOAE. These findings support tailoring universal newborn hearing screening programs in Pakistan to conduct testing on the seventh day of life, reducing false positives and ensuring timely identification of true cases.
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