Evidence map›Paper›PMID 41432870›Full record

ArticleAIDS and behavior2026

Patterns and Predictors of HIV Pre-exposure Prophylaxis (PrEP) Continuity Among Young Women Who Sell Sex in Uganda: A Group-Based Trajectory Modeling Approach.

Joseph G Rosen, Amrita Rao, Hannah Kibuuka, Betty Mwesigwa, Grace Mirembe, Ezra Musingye, Amal Abdulrahman, Stefan D Baral, Trevor A Crowell, Eniko E Akom and 1 more

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Article in AIDS and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joseph G RosenDepartment of Medicine, The Warren Alpert Medical School, Brown University, Providence, RI, USA. joseph_g_rosen@brown.edu.ORCID http://orcid.org/0000-0003-4991-4033
Amrita RaoDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Hannah KibuukaMakerere University Walter Reed Program, Kampala, Uganda.
Betty MwesigwaMakerere University Walter Reed Program, Kampala, Uganda.
Grace MirembeMakerere University Walter Reed Program, Kampala, Uganda.
Ezra MusingyeMakerere University Walter Reed Program, Kampala, Uganda.
Amal AbdulrahmanDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Stefan D BaralDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Trevor A CrowellU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Eniko E AkomU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Katherine B RucinskiDepartment of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Anna Palmer Durbin · 2012 to 2026
$67.0M
The Brown Initiative in HIV and AIDS Clinical Research for Minority CommunitiesR25MH083620 · NIMH · MIRIAM HOSPITAL · PI NUNN, AMY STEWART · 2008 to 2025
$3.7M
Leveraging Big Data Science to Focus the HIV Response in Countries with Generalized HIV EpidemicsR01AI170249 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BARAL, STEFAN DAVID · 2022 to 2025
$2.9M
Implementation Research to Optimize ART Delivery for Adolescents and Young Adults Living with HIVK01MH129226 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Katherine B Rucinski · 2022 to 2026
$792k
Program and implementation context of a housing support initiative to address homelessness and improve HIV service uptake among youth in the United StatesK01MD020002 · NIMHD · JOHNS HOPKINS UNIVERSITY · PI Amrita Rao · 2024 to 2026
$381k
Viral Load Trajectories and Dynamics among People Living with HIV in Rakai, Uganda: A Mixed-Methods StudyF31MH126796 · NIMH · JOHNS HOPKINS UNIVERSITY · PI ROSEN, JOSEPH GREGORY · 2021 to 2022
$79k
National Institute of Allergy and Infectious Diseases P30AI094189National Institute of Allergy and Infectious Diseases R01AI170249NIAID NIH HHS P30 AI094189NIAID NIH HHS R01 AI170249NIMHD NIH HHS K01 MD020002NIMHD NIH HHS K01MD020002NIMH NIH HHS F31 MH126796NIMH NIH HHS F31MH126796NIMH NIH HHS K01 MH129226NIMH NIH HHS K01MH129226NIMH NIH HHS P30MH136191NIMH NIH HHS R25 MH083620U.S. Department of Defense W81XWH-18-2-0040
6 · The paper itself

Abstract

Young women who sell sex (YWSS) in Africa are particularly vulnerable to HIV acquisition and may benefit from daily oral pre-exposure prophylaxis (PrEP) but face multiple barriers to uptake. We identified temporal patterns of PrEP continuity/retention and associated characteristics within a cohort of YWSS in Uganda. Cisgender women aged 18-24 years who exchanged sex for money, goods, or services were recruited into a PrEP demonstration study in peri-urban Mukono District. We used group-based trajectory modeling to discern temporal patterns of PrEP continuity over 12 months of follow-up and multinomial logistic regression to identify baseline predictors of PrEP retention trajectories. Among 833 YWSS initiating PrEP, a four-group trajectory model emerged as best-fitting: (1) Rapid PrEP discontinuity (39.7%), characterized by high PrEP program attrition by 3 months; (2) Delayed PrEP discontinuity (24.2%), characterized by PrEP continuation through 6 months; (3) Immediate PrEP discontinuity (19.1%), characterized by high PrEP discontinuation in the month following initiation; and (4) High PrEP continuity (17.0%), characterized by sustained PrEP engagement throughout follow-up. In general, shorter- and longer-term PrEP continuation was associated with older age, higher education, pre-coital alcohol/drug use, and having 10 + paying partners in the past 3 months. Perceived HIV risk and related HIV vulnerabilities helped distinguish observed PrEP retention trajectories, predicting the timing of PrEP discontinuation among YWSS.

Indexed as

Anti-HIV AgentsHIV InfectionsPre-Exposure ProphylaxisSex WorkSex WorkersAdolescentFemaleHumansMedication AdherenceSexual PartnersUgandaYoung AdultAnti-HIV AgentsAfricaHIV preventionProspective cohortSex work

Identifiers

PMID41432870
PMCPMC12980307

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.