Evidence map›Paper›PMID 41432858›Full record

ArticleJournal of neuro-oncology2025

Predictors of postoperative gustatory disturbance and gustatory recovery following microsurgical resection of vestibular schwannoma.

Sai Chandan Reddy, James Feghali, A Karim Ahmed, S Farzad Maroufi, Jawad M Khalifeh, Austin Carmichael, Eli Yazigi, Melissa Canales, Shaan Bhandarkar, Patrick Kramer and 17 more

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Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

27 authors.

Sai Chandan ReddyDepartment of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street Phipps 102, Baltimore, MD, USA.
James FeghaliDepartment of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street Phipps 102, Baltimore, MD, USA.
A Karim AhmedDepartment of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street Phipps 102, Baltimore, MD, USA.
S Farzad MaroufiDepartment of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street Phipps 102, Baltimore, MD, USA.
Jawad M KhalifehDepartment of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street Phipps 102, Baltimore, MD, USA.
Austin CarmichaelDepartment of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street Phipps 102, Baltimore, MD, USA.
Eli YazigiDepartment of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street Phipps 102, Baltimore, MD, USA.
Melissa CanalesDepartment of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street Phipps 102, Baltimore, MD, USA.
Shaan BhandarkarDepartment of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street Phipps 102, Baltimore, MD, USA.
Patrick KramerDepartment of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street Phipps 102, Baltimore, MD, USA.
Deepa GalaiyaDepartment of Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Bryan K WardDepartment of Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wade ChienDepartment of Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Charles Della SantinaDepartment of Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Daniel Q SunDepartment of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Howard FrancisDepartment of Head and Neck Surgery & Communication Sciences, Duke University School of Medicine, Durham, NC, USA.
C Matthew StewartDepartment of Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Francis CreightonDepartment of Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
John CareyDepartment of Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael LimDepartment of Neurosurgery, Stanford School of Medicine, Stanford, CA, USA.
Risheng XuDepartment of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street Phipps 102, Baltimore, MD, USA.
Justin M CaplanDepartment of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street Phipps 102, Baltimore, MD, USA.
Chetan BettegowdaDepartment of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street Phipps 102, Baltimore, MD, USA.
Jon WeingartDepartment of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street Phipps 102, Baltimore, MD, USA.
Henry BremDepartment of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street Phipps 102, Baltimore, MD, USA.
Rafael J TamargoDepartment of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street Phipps 102, Baltimore, MD, USA.
Christopher M JacksonDepartment of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street Phipps 102, Baltimore, MD, USA. cjacks53@jhmi.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGustatory dysfunction is a complication of vestibular schwannoma (VS) resection and a frequent patient concern, but there is comparatively little in the literature on this topic to guide surgeons in counseling. In this study, we aimed to identify factors contributing to postoperative gustatory dysfunction and subsequent recovery.

methodsWe included consecutive VS patients who underwent microsurgical resection between July 2016 and April 2024 at our institution. Preoperative data included patient demographic information, tumor characteristics, facial nerve function (classified by House-Brackmann (HB) grade), and the presence of gustatory disturbance. Univariable analysis and multivariable logistic regression were used to determine independent predictors of postoperative gustatory disturbance. Cox regression analysis was used to determine predictors of taste recovery.

resultsThe study sample included 433 VS patients who underwent microsurgical resection, of whom 89 (20.6%) reported gustatory disturbance at a median of 32 days postoperatively. Older age, preoperative gustatory disturbance, and mild-to-moderate facial nerve injury (HB grade II or III) at discharge were significantly associated with postoperative gustatory disturbance. By the end of the follow-up period, 71.9% of affected patients had recovered gustatory function at a median time of six months since symptom onset. Older age, particularly > 57 years, was significantly associated with a higher risk of prolonged gustatory disturbance.

conclusionPartial as opposed to complete facial nerve injury may be a stronger predictor of postoperative gustatory disturbance. Patients should be counseled that this complication is typically self-resolving; however, older patients may be at increased risk for prolonged gustatory dysfunction.

Indexed as

MicrosurgeryNeuroma, AcousticNeurosurgical ProceduresPostoperative ComplicationsTaste DisordersAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRecovery of FunctionRetrospective StudiesGustatory disturbanceMicrosurgical resectionPredictorsRecoveryTasteVestibular schwannoma

Identifiers

PMID41432858

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