ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025
The burden of ischemic stroke and its attributable risk factors among people aged 15-49 years in Asia, 1990-2021: results from the global burden of disease study 2021.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Ischemic Stroke Burden in China and Other G20 Nations (1990-2021): A Comparative Analysis From the Global Burden of Disease Study 2021 and Trend Projections Through 2031.Health care science · 2026Article
- Central neuroendocrine dysregulation in ischaemic stroke sequelae: pathophysiological mechanisms-a narrative review.Frontiers in human neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study extensively investigated the disease burden of ischemic stroke (IS) in young and middle-aged populations (15-49 years old) in Asia from 1990 to 2021.
methodsWe used data from the 2021 Global Burden of Disease (GBD) to quantify health burden. Risk factors were analyzed. Joinpoint regression models described the temporal trend of the disease burden. The Bayesian age-period-cohort (BAPC) model was applied for forecasting the disease burden of IS till 2040.
resultsThe incidence of IS among young and middle-aged people in Asia increased by more than 80%, and IS mortality and disability adjusted life years (DALYs) increased by more than 40% over the past 32 years. The rising trend of incidence was the most significant (average annual percentage change [AAPC] = 1.8887, P < 0.001). In 2021, the incidence, mortality, and DALYs in East Asia were the highest. In 2021, the disease burden of males in the age group of 15-49 was greater than that of females, while the 45-49 age group had the most severe disease burden. Risk factor analysis shows that high systolic blood pressure was the biggest risk factor. By 2040, the IS incidence rate among young and middle-aged people aged 15-49 in Asia will reach 25.20, an increase of about 12% compared to 2022.
conclusionFor 15-49-year-old Asians, the disease burden of IS increases continuously. In the future, medical measures for this age group should focus on prevention. This trend will become even more serious if no intervention is applied in the future.
Indexed as
Identifiers
41432816What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.