Evidence map›Paper›PMID 41432786›Full record

ArticleFunctional & integrative genomics2025

Identification of the Nicotianamine synthase (NAS) gene family in wheat (Triticum aestivum L.) and the role of its member TaNAS4-A in Zn and Fe transport.

Gang Liu, Yixuan Sun, Pengyuan He, Yibo Wang, Yixuan Zhang, Qingfeng Li, Fenglou Liu, Shuangxi Zhang, Yingxia Zhang, Caixia Liu and 1 more

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Article in Functional & integrative genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Gang LiuSchool of Agriculture, Ningxia University, Yinchuan, Ningxia, 750021, China.ORCID http://orcid.org/0009-0000-3666-8860
Yixuan SunSchool of Agriculture, Ningxia University, Yinchuan, Ningxia, 750021, China.
Pengyuan HeSchool of Agriculture, Ningxia University, Yinchuan, Ningxia, 750021, China.
Yibo WangSchool of Agriculture, Ningxia University, Yinchuan, Ningxia, 750021, China.
Yixuan ZhangSchool of Agriculture, Ningxia University, Yinchuan, Ningxia, 750021, China.
Qingfeng LiSchool of Agriculture, Ningxia University, Yinchuan, Ningxia, 750021, China.
Fenglou LiuSchool of Agriculture, Ningxia University, Yinchuan, Ningxia, 750021, China.
Shuangxi ZhangSchool of Agriculture, Ningxia University, Yinchuan, Ningxia, 750021, China.
Yingxia ZhangSchool of Agriculture, Ningxia University, Yinchuan, Ningxia, 750021, China.
Caixia LiuSchool of Agriculture, Ningxia University, Yinchuan, Ningxia, 750021, China. liucaixia01@nxu.edu.cn.ORCID http://orcid.org/0000-0002-4314-8318
Zhangjun WangSchool of Agriculture, Ningxia University, Yinchuan, Ningxia, 750021, China. wangzhangjun@nxu.edu.cn.

Funding

National Natural Science Foundation of China 32160452National Natural Science Foundation of China Project 32560455Natural Science Project of Ningxia Institutions of Higher Education NYG2024040Ningxia Natural Science Foundation Project 2024AAC03096
6 · The paper itself

Abstract

Zinc (Zn) and Iron (Fe) are essential trace elements for human health, yet deficiencies in both are widespread worldwide. As a major staple crop, wheat is an important dietary source of Zn and Fe. However, the concentrations of Zn and Fe in common wheat grains are generally low, making it necessary to enhance the nutritional value of wheat. This study first elaborated that both elements are absorbed by wheat via "Strategy II", which relies on phytosiderophores (such as mugineic acids) and related transporter proteins (e.g., YSL and ZIP families). Nicotianamine (NA) plays a key chelating role in the long-distance transport of Zn and Fe. Therefore, we further analyzed the NAS gene family in wheat, which showed high genetic diversity, unique gene structures, distinct evolutionary features, and was subject to purifying selection. Expression profiling revealed that NAS genes were tissue-specific and responsive to various stress conditions. The overexpression of TaNAS4-A in rice, as well as the silencing of TaNAS4-A in wheat using BSMV-VIGS, confirmed the role of TaNAS4-A in enhancing NAS enzyme catalytic efficiency, promoting phytosiderophore secretion, and increasing the accumulation of Zn and Fe in grains. Additionally, this study suggested that NAS genes may confer other functions, such as stress resistance, which deserve further investigation. This research provides a theoretical basis for Zn and Fe biofortification in wheat.

Indexed as

Alkyl and Aryl TransferasesIronPlant ProteinsTriticumZincAzetidinecarboxylic AcidBiological TransportGene Expression Regulation, PlantMultigene FamilyOryzaPhylogenyAlkyl and Aryl TransferasesAzetidinecarboxylic AcidIronnicotianaminenicotianamine synthasePlant ProteinsZincBiofortificationBSMV-VIGSPhytosiderophoresTaNAS4-ATriticum aestivum

Identifiers

PMID41432786

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