ArticleTransfusion2026
Tranexamic acid dosing in pediatric trauma: Dose simulation based on population pharmacokinetic modeling in adult trauma patients.
Article in Transfusion, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
Abstract
backgroundTrauma is the most common cause of death in children >1 year of age, with hemorrhage being the most common preventable cause of death after injury. Antifibrinolytics like tranexamic acid (TXA) are a key aspect of trauma management in children, but optimal dosing remains unknown. The objective of this study was to derive a TXA dose in children with trauma-related bleeding that approximates the TXA exposure in adult trauma patients using a population pharmacokinetic (popPK) model from adults with severe traumatic injury. STUDY DESIGN AND
methodsModel-based simulation was performed by extrapolating a previously published popPK model of TXA in adults with trauma-related bleeding to pediatric patients. A virtual pediatric trauma population was simulated utilizing published covariate values and an allometrically scaled adult model applied to predict the TXA PK profile in children with trauma-related bleeding.
resultsAn IV TXA bolus of 25 mg/kg (max 2 g) in children with trauma-related bleeding approximates the C DISCUSSION: In children with trauma-related bleeding, a TXA 25 mg/kg IV bolus is predicted to approximate the C
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