Expanding the Chemical Space of Cyclic Polyphthalaldehyde via Post-Functionalization.

Liting He, Haiyan Zhou, Qiushi Chen, Xing Guo, Han Liu, Xuechen Li

Abstract read

In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Liting HeDepartment of Chemistry, The State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, P. R. China.

Haiyan ZhouDepartment of Chemistry, The State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, P. R. China.

Qiushi ChenDepartment of Chemistry, The State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, P. R. China.

Xing GuoDepartment of Chemistry, The State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, P. R. China.

Han LiuDepartment of Chemistry, The State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, P. R. China.

Xuechen LiDepartment of Chemistry, The State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, P. R. China.ORCID https://orcid.org/0000-0001-5465-7727

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cyclic polyphthalaldehydes (cPPAs) are hydrophobic cyclic polymers with stimuli-responsive depolymerization property. The introduction of hydrophilic functionalities to cPPAs is challenging due to the intrinsic limitation of cationic polymerization. Herein, we developed a post-functionalization approach to achieve water-soluble cPPA derivatives with high molecular weight. The cPPA modified with cell-penetrating oligoarginine underwent cellular uptake via endocytosis and acid-triggered depolymerization in lysosome, which provided new potential for biological application.

Indexed as

click chemistrycyclic polymerpoly‐o‐phthalaldehydepost‐functionalizationwater soluble

Identifiers

PMID41432659

DOI10.1002/advs.202522465

PMCPMC12955877

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.