Evidence map›Paper›PMID 41432563›Full record

Trial reportRadiology2025

Statins Reduce Wall Enhancement at Vessel Wall MRI in Unruptured Vertebrobasilar Dissecting Aneurysms: A Randomized Controlled Trial.

Yisen Zhang, Chao Wang, Linggen Dong, Mirzat Turhon, Huibin Kang, Jian Liu, Yunyun Duan, Decai Tian, Binbin Sui, Ying Zhang and 4 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yisen Zhang *Department of Neurosurgery and Department of Interventional Neuroradiology, Beijing Tiantan Hospital and Beijing Neurosurgical Institute, Capital Medical University, NansihuanXilu 119, Fengtai District, Beijing, China 100070.ORCID 0000-0002-6685-0126
Chao Wang *Department of Neurosurgery and Department of Interventional Neuroradiology, Beijing Tiantan Hospital and Beijing Neurosurgical Institute, Capital Medical University, NansihuanXilu 119, Fengtai District, Beijing, China 100070.ORCID 0000-0002-9954-5881
Linggen DongDepartment of Neurosurgery and Department of Interventional Neuroradiology, Beijing Tiantan Hospital and Beijing Neurosurgical Institute, Capital Medical University, NansihuanXilu 119, Fengtai District, Beijing, China 100070.ORCID 0000-0002-8943-9989
Mirzat TurhonDepartment of Neurosurgery and Department of Interventional Neuroradiology, Beijing Tiantan Hospital and Beijing Neurosurgical Institute, Capital Medical University, NansihuanXilu 119, Fengtai District, Beijing, China 100070.ORCID 0000-0003-4183-6026
Huibin KangDepartment of Neurosurgery, Southern Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0001-9994-1326
Jian LiuDepartment of Neurosurgery and Department of Interventional Neuroradiology, Beijing Tiantan Hospital and Beijing Neurosurgical Institute, Capital Medical University, NansihuanXilu 119, Fengtai District, Beijing, China 100070.ORCID 0000-0002-5454-2847
Yunyun DuanDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Decai TianDepartment of Neurology, Tiantan Neuroimaging Center of Excellence, Beijing, China.ORCID 0000-0002-5153-2491
Binbin SuiDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-1052-6992
Ying ZhangDepartment of Neurosurgery and Department of Interventional Neuroradiology, Beijing Tiantan Hospital and Beijing Neurosurgical Institute, Capital Medical University, NansihuanXilu 119, Fengtai District, Beijing, China 100070.ORCID 0000-0002-5812-372X
Kun WangDepartment of Neurosurgery and Department of Interventional Neuroradiology, Beijing Tiantan Hospital and Beijing Neurosurgical Institute, Capital Medical University, NansihuanXilu 119, Fengtai District, Beijing, China 100070.
Mahmud Mossa-BashaDepartment of Radiology, University of Washington School of Medicine, Seattle, Wash.ORCID 0000-0001-7798-8158
Xinjian Yang *Department of Neurosurgery and Department of Interventional Neuroradiology, Beijing Tiantan Hospital and Beijing Neurosurgical Institute, Capital Medical University, NansihuanXilu 119, Fengtai District, Beijing, China 100070.ORCID 0000-0001-7306-0125
Chengcheng Zhu *Department of Radiology, University of Washington School of Medicine, Seattle, Wash.ORCID 0000-0001-6898-549X

Funding

Investigation of the quantitative intracranial aneurysm wall enhancement and geometric features associated with aneurysm volume growthR01HL162743 · NHLBI · UNIVERSITY OF WASHINGTON · PI Chengcheng Zhu · 2022 to 2026
$2.4M
NHLBI NIH HHS R01 HL162743
6 · The paper itself

Abstract

Background Vertebrobasilar dissecting aneurysms (VBDAs) are important causes of stroke. Aneurysm wall enhancement at vessel wall (VW) MRI is a marker of inflammation. Previous studies have shown that statins may reduce inflammation in intracranial saccular aneurysms, but their effect on VBDAs remains unknown. Purpose To evaluate the effect of 6-month atorvastatin treatment on VBDA wall enhancement on VW MRI scans. Materials and Methods Participants with unruptured VBDAs were enrolled in this open-label, randomized controlled trial from July 2021 to January 2023 and randomized 1:1 to the daily 20 mg atorvastatin group or control group. VBDAs were imaged with VW MRI at baseline and at the 6-month follow-up. The primary end point was the change in aneurysm wall enhancement measured by the quantitative wall enhancement index (WEI) and three-dimensional wall enhancement volume rate (WEVR). The secondary outcomes were changes in aneurysm size or morphology and inflammation-related circulating biomarkers. All outcome analyses were performed using appropriate tests for categorical and continuous variables. Results A total of 40 participants were included (mean age, 52 years ± 11 [SD]; 34 men). In the statin group, both the WEI and WEVR of the aneurysm wall decreased at 6 months compared with those at baseline. The change in WEI was -0.3 in the statin group but 0.1 in the control group (

Indexed as

Aortic DissectionAtorvastatinHydroxymethylglutaryl-CoA Reductase InhibitorsIntracranial AneurysmMagnetic Resonance ImagingVertebral Artery DissectionAdultFemaleHumansMaleMiddle AgedAtorvastatinHydroxymethylglutaryl-CoA Reductase Inhibitors

Identifiers

PMID41432563
PMCPMC13267880

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.