SynthesisThe Journal of clinical endocrinology and metabolism2026
The effect of hypercortisolism treatment on dyslipidemia in Cushing syndrome: systematic review and meta-analysis.
Synthesis in The Journal of clinical endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of hypercortisolism treatment on dyslipidemia in Cushing syndrome: systematic review and meta-analysis.The Journal of clinical endocrinology and metabolism · 2026Pooled it
- Minimally invasive adrenalectomy for Cushing's syndrome and mild autonomous cortisol secretion: a 20-year experience from a tertiary endocrine surgery center.BMC surgery · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCushing syndrome (CS) is a clinical condition caused by increased plasma cortisol levels and characterized by high cardiovascular mortality. Among the metabolic effects of CS and its treatment, glycemic disturbances have been investigated in depth, while data on dyslipidemia is still lacking.
objectivesOur study aims at evaluating the effects of CS treatment on serum lipid levels. MATERIALS AND
methodsA literature search was conducted using PubMed, Scopus, and EMBASE databases to investigate the effects of CS treatment on serum total cholesterol (TC), low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides. Before-after analysis and subgroup analysis were performed.
resultsTwenty-nine observational or interventional studies (51.7% of good quality) were included in the quantitative analysis. Treatment of CS led to clinically and statistically significant decrease in serum TC (mean difference [MD] -26.49; 95% CI, -29.95 to -23.04; P < .00001), low-density lipoprotein cholesterol (MD -18.44; 95% CI, -21.30 to -15.57; P < .00001), and triglycerides levels (MD -17.77; 95% CI, -22.70 to -12.84; P < .00001), with no significant changes in high-density lipoprotein cholesterol levels (MD -2.34; 95% CI, -6.96 to 2.28; P = .32). Subgroup analysis showed greater decrease in TC levels in subjects with adrenal hypercortisolism, in those treated with steroidogenesis inhibitors, and in those with treatment duration ≥12 months. In addition, CS treatment significantly decreased blood glucose levels, body mass index, waist circumference, and insulin resistance index.
conclusionOur study demonstrates a significant improvement in serum lipid levels after treatment of CS. Because the cardiovascular complications of hypercortisolism depend on several factors, further studies are needed to determine whether this directly translates into an adequate reduction in the risk of major cardiovascular events.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.