Evidence map›Paper›PMID 41432447›Full record

ArticleMicrobiology spectrum2026

Exploring the activity of a novel orally bioavailable β-lactam-β-lactamase inhibitor combination, ceftibuten-ledaborbactam, against Enterobacterales-carrying

Maria F Mojica, Elise T Zeiser, Scott A Becka, David A Six, Greg Moeck, Robert A Bonomo, Krisztina M Papp-Wallace

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maria F MojicaDepartment of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0002-1380-9824
Elise T ZeiserResearch Service, Veterans Affairs Northeast Ohio Healthcare System, Cleveland, Ohio, USA.
Scott A BeckaResearch Service, Veterans Affairs Northeast Ohio Healthcare System, Cleveland, Ohio, USA.
David A SixVenatorx Pharmaceuticals Inc., Malvern, Pennsylvania, USA.ORCID 0000-0002-9013-1711
Greg MoeckVenatorx Pharmaceuticals Inc., Malvern, Pennsylvania, USA.ORCID 0000-0001-7827-7227
Robert A BonomoDepartment of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0002-3299-894X
Krisztina M Papp-WallaceResearch Service, Veterans Affairs Northeast Ohio Healthcare System, Cleveland, Ohio, USA.ORCID 0000-0002-9976-7898

Funding

Broad-spectrum, Orally Bioavailable Beta-lactamase Inhibitors for BiodefenseR01AI111539 · NIAID · VENATORX PHARMACEUTICALS, INC. · PI BURNS, CHRISTOPHER JOHN, XERRI, LUIGI · 2014 to 2017
$6.1M
Advancement to IND of novel BLI for pairing with cefiximeR44AI109879 · NIAID · VENATORX PHARMACEUTICALS, INC. · PI XERRI, LUIGI · 2017 to 2019
$3.0M
BLRD VA I01 BX001974BLRD VA I01 BX002872National Institute of Allergy and Infectious Diseases 5R44AI109879-04A1National Institute of Allergy and Infectious Diseases R01AI111539NIAID NIH HHS R01 AI111539NIAID NIH HHS R44 AI109879NIH HHS HHSN272201600029CODCDC CDC HHS HHSN272201600029CU.S. Department of Veterans Affairs 1I01BX001974U.S. Department of Veterans Affairs 1I01BX002872
6 · The paper itself

Abstract

Ledaborbactam is a novel boronic-acid inhibitor of class A, C, and D β-lactamases, including OXA-48, being developed in combination with ceftibuten. Herein, we examined the

Indexed as

Anti-Bacterial Agentsbeta-Lactamase Inhibitorsbeta-LactamasesCeftibutenEnterobacteriaceaeAdministration, OralBacterial Proteinsbeta-LactamsDrug CombinationsEnterobacteriaceae InfectionsHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial Proteinsbeta-Lactamase Inhibitorsbeta-Lactamasesbeta-LactamsCeftibutenDrug CombinationscarbapenemaseCeftibuten-ledaborbactamEnterobacteralesOXA-48β-lactamβ-lactamase inhibitorβ-lactamases

Identifiers

PMID41432447
PMCPMC12889136

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.