Evidence map›Paper›PMID 41432418›Full record

ArticleJournal of bacteriology2026

Ashley S Weiss, Jilarie A Santos-Santiago, Orlaith Keenan, Alexander B Smith, Montana Knight, Joseph P Zackular, Rita Tamayo

Abstract read
In one paragraph

Article in Journal of bacteriology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. A programmed reset mechanism primesScience advances · 2026
    Article
  2. Phase variable colony morphotypes ofInfection and immunity · 2026
    Article
  3. Contact dependent suppression ofbioRxiv : the preprint server for biology · 2026
    Article
  4. Phase variable colony morphotypes ofbioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

  • Update of
    2025
5 · Who and what money

Authors and funding

7 authors.

Ashley S Weiss *Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0009-0008-7162-4829
Jilarie A Santos-Santiago *Department of Microbiology and Immunology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-1328-0174
Orlaith KeenanDivision of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Alexander B SmithDivision of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Montana KnightDepartment of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Joseph P Zackular *Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-3228-3055
Rita Tamayo *Department of Microbiology and Immunology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-3745-3316

Funding

Project 3: Defining adaptive immune interactions that shape Clostridioides difficile infectionU19AI174998 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DREW WEISSMAN · 2023 to 2026
$7.6M
Molecular interactions in the gut microbiota during early life colonization and perturbationR35GM138369 · NIGMS · CHILDREN'S HOSP OF PHILADELPHIA · PI Joseph Paul Zackular · 2020 to 2026
$2.7M
Global regulation in Clostridium difficile via phase variation of cyclic diguanylate signalingR01AI143638 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TAMAYO, RITA · 2019 to 2023
$2.5M
Defining the role of enterococci in reshaping Clostridioides difficile infectionR01AI187174 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI Boone M. Prentice, Joseph Paul Zackular · 2025 to 2026
$1.6M
Defining the role of phenotypic heterogeneity in Clostridioides difficile fitnessR01AI188648 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RITA TAMAYO · 2025 to 2026
$1.1M
NIAID NIH HHS R01 AI143638NIAID NIH HHS R01 AI187174NIAID NIH HHS R01 AI188648NIAID NIH HHS U19 AI174998NIGMS NIH HHS R35 GM138369NIH HHS K22-AI7220NIH HHS R01-AI143638NIH HHS R01-AI187174NIH HHS R01-AI188648NIH HHS R35-GM138369NIH HHS U19-AI174998
6 · The paper itself

Abstract

To adapt and persist in the gastrointestinal tract, many enteric pathogens, including

Indexed as

Clostridioides difficileEnterococcus faecalisMicrobial InteractionsBacterial ProteinsGastrointestinal MicrobiomeGene Expression Regulation, BacterialPhenotypeSignal TransductionBacterial Proteinscolony morphologyphase variationpolymicrobial interactionssurface motility

Identifiers

PMID41432418
PMCPMC12826044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.