ArticlemSphere2025
NapR, a novel nucleoid-associated protein, regulates antioxidant defense in mycobacteria.
Kun Wang, Xujie Cui, Xiangyang Zhang, Jiachen Zheng, Xiaocui Ling, Yunfan Zhang, Pengbo Yu, Boyan Lv, Weihui Li
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In one paragraphArticle in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
Kun Wang *College of Life Science and Technology, Guangxi University, Guangxi Research Center for Microbial and Enzyme Engineering Technology, State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Nanning, China.
Xujie Cui *College of Life Science and Technology, Guangxi University, Guangxi Research Center for Microbial and Enzyme Engineering Technology, State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Nanning, China.ORCID 0000-0002-8805-1341 Xiangyang ZhangCollege of Life Science and Technology, Guangxi University, Guangxi Research Center for Microbial and Enzyme Engineering Technology, State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Nanning, China.
Jiachen ZhengCollege of Life Science and Technology, Guangxi University, Guangxi Research Center for Microbial and Enzyme Engineering Technology, State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Nanning, China.
Xiaocui LingCollege of Life Science and Technology, Guangxi University, Guangxi Research Center for Microbial and Enzyme Engineering Technology, State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Nanning, China.
Yunfan ZhangCollege of Life Science and Technology, Guangxi University, Guangxi Research Center for Microbial and Enzyme Engineering Technology, State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Nanning, China.
Pengbo YuCollege of Life Science and Technology, Guangxi University, Guangxi Research Center for Microbial and Enzyme Engineering Technology, State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Nanning, China.
Boyan LvCollege of Life Science and Technology, Guangxi University, Guangxi Research Center for Microbial and Enzyme Engineering Technology, State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Nanning, China.ORCID 0000-0002-6451-7362 Weihui LiCollege of Life Science and Technology, Guangxi University, Guangxi Research Center for Microbial and Enzyme Engineering Technology, State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Nanning, China.ORCID 0000-0001-7037-7610 Funding
Ba-Gui Youth Talent Support Program of GuangxiGuangxi Science Fund for Distinguished Young Scholars 2022JJG130005Innovation Project of Guangxi Graduate Education YCSW2024035National Natural Science Foundation of China 32470034, 32360013
6 · The paper itselfAbstract
Nucleoid-associated proteins (NAPs) are essential in bacteria for maintaining nucleoid architecture and regulating the expression of target genes. Although some NAPs have been well studied in certain bacterial species, their specific functions and regulatory mechanisms remain poorly characterized in mycobacteria. In this study, we identified NapR as a novel nucleoid-associated protein in mycobacteria. We showed that NapR, which is highly conserved among mycobacteria, binds DNA and modulates DNA topology through bridging. Furthermore, we demonstrated that NapR acts as a positive transcriptional regulator of the
Indexed as
AntioxidantsBacterial ProteinsDNA-Binding ProteinsGene Expression Regulation, BacterialMycobacteriumMycobacterium smegmatisOxidative StressReactive Oxygen SpeciesAntioxidantsBacterial ProteinsDNA-Binding ProteinsReactive Oxygen Speciesantioxidant defensegeranylgeranyl reductasemycobacteriatranscriptional regulation
Identifiers
PMID41432406
PMCPMC12724333
What OpenQuestion holds
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LicenceCC BY
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