Evidence map›Paper›PMID 41432249›Full record

ArticleChemical biology & drug design2025

Antidiabetic Evaluation of New Pyrimidine-Thiazoline Hybrids Endorsed With Enzyme Kinetic Studies and Computational Analysis.

Gobind Kumar, Pule Seboletswe, Neha Manhas, Safiyah Ghumran, Nontobeko Gcabashe, Gaurav Bhargava, Almahi Idris, Md Shahidul Islam, Parvesh Singh

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In one paragraph

Article in Chemical biology & drug design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gobind KumarSchool of Chemistry and Physics, University of KwaZulu Natal, Westville, Durban, South Africa.
Pule SeboletsweSchool of Chemistry and Physics, University of KwaZulu Natal, Westville, Durban, South Africa.
Neha ManhasSchool of Chemistry and Physics, University of KwaZulu Natal, Westville, Durban, South Africa.
Safiyah GhumranSchool of Chemistry and Physics, University of KwaZulu Natal, Westville, Durban, South Africa.
Nontobeko GcabasheSchool of Chemistry and Physics, University of KwaZulu Natal, Westville, Durban, South Africa.
Gaurav BhargavaDepartment of Chemistry, I. K. Gujral Punjab Technical University, Kapurthala, Punjab, India.ORCID https://orcid.org/0000-0001-9128-8596
Almahi IdrisDepartment of Biochemistry, School of Life Sciences, University of Kwazulu-Natal, Westville, Durban, South Africa.ORCID https://orcid.org/0000-0002-9918-5409
Md Shahidul IslamDepartment of Biochemistry, School of Life Sciences, University of Kwazulu-Natal, Westville, Durban, South Africa.ORCID https://orcid.org/0000-0003-0309-9491
Parvesh SinghSchool of Chemistry and Physics, University of KwaZulu Natal, Westville, Durban, South Africa.ORCID https://orcid.org/0000-0001-6742-6389

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of diabetes mellitus (DM) poses a serious global health concern, given its substantial contribution to mortality rates. Millions of people worldwide are affected by this disease, which is associated with severe complications. Among the different strategies used to regulate diabetes, inhibition of carbohydrate-hydrolyzing enzymes (α-glucosidase and α-amylase) has emerged as a promising therapeutic alternative. Accordingly, the present study explored the concept of molecular hybridization for synthesizing new pyrimidine-thiazole molecular hybrids as potential α-glucosidase and α-amylase inhibitors and antioxidant agents. Among the tested hybrids, compound 8j emerged as the most potent inhibitor with 3-fold (IC

Indexed as

alpha-AmylasesGlycoside Hydrolase InhibitorsHypoglycemic AgentsPyrimidinesThiazolesAcarbosealpha-GlucosidasesAntioxidantsHumansKineticsMolecular Docking SimulationStructure-Activity RelationshipAcarbosealpha-Amylasesalpha-GlucosidasesAntioxidantsGlycoside Hydrolase InhibitorsHypoglycemic AgentspyrimidinePyrimidinesThiazolesADME/Tantidiabetic activityDFT calculationsmolecular dockingα‐amylaseα‐glucosidase

Identifiers

PMID41432249
PMCPMC12724058

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.