ArticleJournal of the American Chemical Society2026
Direct Aziridine Synthesis from Amines and Styrene Derivatives via a Base-Promoted Oxidative Cascade Reaction.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Base-Promoted Benzylic C-H Amination Reactions Across a Wide pKa Spectrum Enabled by 2-Halobenzofuran and -Indole Oxidants.Journal of the American Chemical Society · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
We report a base-promoted protocol for direct aziridine synthesis from primary amines and styrene derivatives. The reaction proceeds via base-promoted styrene hydroamination to generate a β-arylamine intermediate that undergoes deprotonative benzylic halogenation followed by cyclization to an aziridine. A Curtin-Hammett oxidative scenario underpins this cascade process, where 2-halothiophenes selectively transfer a halogen to transient benzylic carbanionic species generated in the presence of amine anions. This unique oxidative strategy provides new and complementary synthetic capabilities over established aziridination methods that rely on alkene or amine oxidation. Most importantly, abundantly available primary anilines and alkylamines are used to directly access aziridines with diverse
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