Evidence map›Paper›PMID 41432171›Full record

ArticleThe Journal of organic chemistry2026

A Concise Route to Orthogonally Protected Bulgecinine.

Qiuyun Yang, Pradip Shit, Van T Nguyen, Allen G Oliver, Jed F Fisher, Shahriar Mobashery

Abstract read
In one paragraph

Article in The Journal of organic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qiuyun YangDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Pradip ShitDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Van T NguyenDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Allen G OliverDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID 0000-0002-0511-1127
Jed F FisherDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Shahriar MobasheryDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID 0000-0002-7695-7883

Funding

Bulgecin Template for Potentiation of beta-Lactam AntibioticsR01AI148217 · NIAID · UNIVERSITY OF NOTRE DAME · PI MOBASHERY, SHAHRIAR · 2020 to 2024
$3.0M
NIAID NIH HHS R01 AI148217
6 · The paper itself

Abstract

Bulgecinine is the core structure for inhibitors of the important lytic transglycosylases of bacterial cell-envelope homeostasis. Their central pyrrolidine ring mimics, as the protonated amine, the transient oxocarbenium species of the enzymatic reaction. We report a concise synthesis of protected bulgecinine

Indexed as

PyrrolidinesCrystallography, X-RayMolecular StructureStereoisomerismPyrrolidines

Identifiers

PMID41432171
PMCPMC13312208

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.