ArticleCell biochemistry and function2025
Acidic pH Greatly Enhances Calbindin-D28K's Inhibitory Effect on Caspase-3: Implications for Alzheimer's Therapeutics.
Article in Cell biochemistry and function, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Acidic pH Greatly Enhances Calbindin-D28K's Inhibitory Effect on Caspase-3: Implications for Alzheimer's Therapeutics.Cell biochemistry and function · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
In Alzheimer's disease (AD), the interaction between many AD-relevant proteins, including amyloid precursor protein (APP) and tau, with the cysteine protease caspase-3 (Cas3) enhances AD pathogenesis. Searching for effective Cas3 inhibitors, we turned to the sensor calbindin-D28K (D28K) which specifically inhibits Cas3. The specific D28K conformation that elicits Cas3 inhibition remains elusive. To shed more light on this D28K conformation, we investigated likely environmental regulators. Recently, evidence of pH imbalance in aging brains has been implicated in AD pathologies. Using pull-down assays, Cas3 inhibition assays, and molecular docking, we identified pH as a critical regulator for tuning the strength of D28K's inhibitory actions and subsequently identified Loop4 in Cas3 as the structural element targeted by D28K.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.