Evidence map›Paper›PMID 41432060›Full record

ArticleThe Journal of general virology2025

Co-presence of classical scrapie but not classical Bovine Spongiform Encephalopathy in transmissions from Dutch sheep with atypical scrapie.

Lucien J van Keulen, Corry H Dolstra, Ruth Bossers-de Vries, Alex Bossers

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of general virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lucien J van KeulenWageningen Bioveterinary Research, Wageningen University and Research Centre, Lelystad, The Netherlands.
Corry H DolstraWageningen Bioveterinary Research, Wageningen University and Research Centre, Lelystad, The Netherlands.
Ruth Bossers-de VriesWageningen Bioveterinary Research, Wageningen University and Research Centre, Lelystad, The Netherlands.
Alex BossersWageningen Bioveterinary Research, Wageningen University and Research Centre, Lelystad, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two cases of atypical scrapie (AS) from Dutch sheep were passaged to WT mice and ovine and bovine prion protein (PrP) transgenic mice. Both AS isolates failed to transmit to WT mice but were successfully transmitted to ovine PrP transgenic Tg338 and Tg59 mice, carrying two different sheep PrP alleles. Western blot analysis of the brains from both mouse lines showed a similar protease-resistant band of ~6-8 kDa, which corresponded to the amino acids ~93-155 of the ovine PrP. Sagittal and coronal immunohistochemical profiles of the abnormal scrapie-associated PrP (PrP

Indexed as

Encephalopathy, Bovine SpongiformScrapieAnimalsBlotting, WesternBrainCattleImmunohistochemistryMiceMice, TransgenicPrPSc ProteinsSheepPrPSc Proteinsatypical scrapie (AS)classical scrapie (CS)prionprotease-resistant prion protein (PrPres)scrapie-associated prion protein (PrPSc)transgenic mice

Identifiers

PMID41432060
PMCPMC12723909

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.