Evidence map›Paper›PMID 41432054›Full record

ArticleeLife2025

GPR30 in spinal cholecystokinin-positive neurons modulates neuropathic pain.

Qing Chen, Hui Wu, Shulan Xie, Fangfang Zhu, Fang Xu, Qi Xu, Lihong Sun, Yue Yang, Linghua Xie, Jiaqian Xie and 9 more

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Qing Chen *Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Hui Wu *Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID https://orcid.org/0000-0003-4907-3625
Shulan Xie *Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Fangfang ZhuDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Fang XuDepartment of Anesthesiology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Qi XuDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Lihong SunDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yue YangDepartment of Anesthesiology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, China.
Linghua XieDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jiaqian XieDepartment of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Hua LiDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Ange DaiDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Wenxin ZhangDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Luyang WangDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Cuicui JiaoDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
HongHai ZhangDepartment of Anesthesiology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, China.ORCID https://orcid.org/0000-0003-3530-2060
Xuelong ZhouDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhen-Zhong XuNANHU Brain-Computer Interface Institute, Hangzhou, China.ORCID https://orcid.org/0000-0001-6578-211X
Xinzhong ChenDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID https://orcid.org/0000-0001-9219-1681

Funding

4+X Clinical Research Project of Women's Hospital, School of Medicine, Zhejiang University ZDFY2022-4XA102Fundamental Research Funds for the Central Universities 2023ZFJH01-01Fundamental Research Funds for the Central Universities 2024ZFJH01-01Fundamental Research Funds for the Central Universities 226-2022-00227National Natural Science Foundation of China 82171206National Natural Science Foundation of China 82371220
6 · The paper itself

Abstract

Neuropathic pain, a major health problem affecting 7-10% of the global population, lacks effective treatment due to its elusive mechanisms. Cholecystokinin-positive (CCK

Indexed as

CholecystokininNeuralgiaNeuronsReceptors, EstrogenReceptors, G-Protein-CoupledSpinal CordAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLCholecystokininGPER1 protein, mouseReceptors, EstrogenReceptors, G-Protein-CoupledAi14C57BL/6JCCK-Cremedicinemouseneuroscience

Identifiers

PMID41432054
PMCPMC12726830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.