ArticleJournal of epilepsy research2025
Comparative Assessment of Quality of Life and Serum S100B in Epilepsy Treated with Newer and Conventional Drugs: A Pharmacoeconomic Perspective.
Article in Journal of epilepsy research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Purpose: S100B is a cytokine produced by astrocytes following glial and neuronal damage. This study aims to evaluate the impact of anti-epileptic drugs (AEDs) on serum S100B levels and health-related quality of life (HRQoL) indices. Methods: In this prospective observational study, serum S100B levels were compared between persons with epilepsy (PWE) and healthy controls. In the PWE group, serum S100B levels and HRQoL using patient weighted quality of life in epilepsy (QOLIE-10-P), pittsburgh sleep quality index (PSQI), and liverpool adverse event profile (LAEP) scores were assessed at baseline and after 12 weeks of AEDs treatment. Results: The mean baseline serum S100B level in the PWE group was 0.093±0.031 μg/L, significantly higher than in the control group, 0.050±0.020 μg/L. In PWE, after 12 weeks of treatment, this level decreased by 17.20% ( Conclusions: Over 12 weeks of AED therapy, PWE demonstrated significant reductions in both serum S100B levels and seizure frequency. While conventional and newer AEDs yielded comparable improvements in HRQoL, newer AEDs conferred an advantage in sleep quality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.