Evidence map›Paper›PMID 41431648›Full record

SynthesisPeerJ2025

A systematic review of the role of methylase genes in antibiotic resistance: co-existence with extended spectrum β-lactamase and carbapenemase genes in

Nur Husna Shahimi, Nabiha Bouafia, Mawaddah Mohd Azlan, Asma Nadia Ahmad Faris, Nur Ayunie Ahmad, Ali Rabaan, Amal Alfaraj, Bandar Albaradi, Tasneem Zaidan, Abdulsalam Alawfi and 7 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Colistin use and outcomes in Kuwait public hospitals.Frontiers in drug safety and regulation · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Nur Husna ShahimiInstitute for Research in Molecular Medicine (INFORMM), Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Nabiha BouafiaInfection Prevention and Control Centre of Excellence, Prince Sultan Medical Military City, Riyadh, Saudi Arabia.
Mawaddah Mohd AzlanInstitute for Research in Molecular Medicine (INFORMM), Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Asma Nadia Ahmad FarisInstitute for Research in Molecular Medicine (INFORMM), Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Nur Ayunie AhmadInstitute for Research in Molecular Medicine (INFORMM), Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Ali RabaanMolecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.
Amal AlfarajPediatric Department, Abqaiq General Hospital, First Eastern Health Cluster, Abqaiq, Saudi Arabia.
Bandar AlbaradiDepartment of Pediatric Infectious Diseases, King Fahad Specialist Hospital, Dammam, Saudi Arabia.
Tasneem ZaidanPediatric Infectious Diseases Unit, Pediatric Department, King Abdulaziz Hospital, Jeddah, Saudi Arabia.
Abdulsalam AlawfiDepartment of Pediatrics, College of Medicine, Taibah University, Al-Madinah, Saudi Arabia.
Amer AlshengetiDepartment of Pediatrics, College of Medicine, Taibah University, Al-Madinah, Saudi Arabia.
Zainab AlmansourBiological Science Department, College of Science, King Faisal University, Hofuf, Saudi Arabia.
Wadha AlfouzanDepartment of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait.
Amal SabourDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Maha AlshiekheidDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Anizah RahumatullahInstitute for Research in Molecular Medicine (INFORMM), Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Nik Yusnoraini YusofInstitute for Research in Molecular Medicine (INFORMM), Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Antibiotic resistance in multidrug-resistant Methods: A literature search was conducted across three electronic databases from inception until 6 December 2023. The quality assessment followed Critical Appraisal Skills Programme (CASP) criteria. Studies focusing on methylase genes and antibiotic resistance in Results: Thirty-four studies met the inclusion criteria. Methylase genes in Conclusions: The widespread distribution of resistance mechanisms in

Indexed as

Bacterial Proteinsbeta-LactamasesDrug Resistance, Multiple, BacterialKlebsiella pneumoniaeMethyltransferasesAnti-Bacterial AgentsHumansKlebsiella InfectionsMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasescarbapenemaseMethyltransferases16S rRNA methyltransferaseCarbapenemaseExtended-Spectrum-Beta-LactamasesExtended-Spectrum-β-LactamasesKlebsiella pneumoniae

Identifiers

PMID41431648
PMCPMC12718525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.