ArticleBMJ public health2025
Multicountry surveillance study of acute febrile disease of unknown cause in sub-Saharan Africa.
Article in BMJ public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Epidemiological investigation of Shuni virus infections in hospitals in two provinces of South Africa (2019-2021) using molecular and serological surveillance.PLoS neglected tropical diseases · 2026Article
- Rickettsia typhi seroprevalence among patients with unexplained acute fever at the Sourô Sanou University Hospital Center (SSUHC), Burkina Faso.BMC infectious diseases · 2026Article
- Next-Generation HIV-1 Therapeutics in Co-Endemic Settings.Biomedicines · 2026Review
- Using nanopore metagenomics to characterize pathogens in febrile patients from a highland of Western Kenya.Frontiers in cellular and infection microbiology · 2026Article
Corrections and comments
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Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Acute Febrile Disease of Unknown Cause (AFDUC) remains a major diagnostic and clinical challenge in sub-Saharan Africa (SSA), where malaria dominates while other aetiologies are under-recognised. The African Network for Improved Diagnostics, Epidemiology and Management of common Infectious Agents aimed to enhance understanding of the epidemiology of AFDUC in SSA through clinical and laboratory-based surveillance. Methods: A multicentre prospective sentinel surveillance case-control study was conducted across urban and rural sites in Côte d'Ivoire (CI), Burkina Faso (BF) and South Africa (SA). We enrolled 6100 AFDUC cases and 1455 healthy controls between 2018 and 2022 across all study sites. Standardised clinical, laboratory and follow-up data were collected. Diagnostics included biomolecular multiplex PCR, serology and blood culture. Associations between pathogens and AFDUC were assessed using adjusted odds ratios. Results: Conclusions: Our results highlight the need for improved diagnostics of common and zoonotic pathogens in SSA and provide insights into febrile disease aetiologies. Strengthened laboratory surveillance, improved case management and targeted vector control are critical to reduce the burden of febrile illness.
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