Evidence map›Paper›PMID 41431550›Full record

ArticleCureus2025

Paraneoplastic Leukemoid Reaction in Lung Adenocarcinoma With Multi-lineage Granulocytic Abnormalities and Eosinophilic Pleural Effusion.

Yongqiu Duan, Yang Yang, Hongwei Yu, Chunxiu Zhang, Yiting Wang, Min Ruan, Zeng Yunyan

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yongqiu DuanDepartment of Respiratory and Critical Care Medicine, The Second People's Hospital of Baoshan, Baoshan, CHN.
Yang YangDepartment of Respiratory and Critical Care Medicine, The Second People's Hospital of Baoshan, Baoshan, CHN.
Hongwei YuDepartment of Respiratory and Critical Care Medicine, The Second People's Hospital of Baoshan, Baoshan, CHN.
Chunxiu ZhangDepartment of Respiratory and Critical Care Medicine, The Second People's Hospital of Baoshan, Baoshan, CHN.
Yiting WangDepartment of Respiratory and Critical Care Medicine, The Second People's Hospital of Baoshan, Baoshan, CHN.
Min RuanDepartment of Respiratory and Critical Care Medicine, The Second People's Hospital of Baoshan, Baoshan, CHN.
Zeng YunyanDepartment of Respiratory and Critical Care Medicine, The Second People's Hospital of Baoshan, Baoshan, CHN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This report describes a rare and lethal phenotype of paraneoplastic leukemoid reaction (PLR) in lung adenocarcinoma, defined by a triad of multi-lineage myeloid proliferation, marked eosinophilic malignant pleural effusion, and progressive lymphopenia. The patient presented with a hyper-aggressive clinical course, culminating in a fatal outcome within 12 days, suggesting an underlying multi-cytokine storm. Clinically, this triad serves as a critical alert for distinguishing PLR from infection and underscores the importance of early bone marrow evaluation for rapid diagnosis. This case highlights the urgent need for mechanistic studies of multi-cytokine-driven PLR.

Indexed as

eosinophilic pleural effusionlung adenocarcinomamulti-lineage granulocytic proliferationparaneoplastic leukemoid reactionrapid progression

Identifiers

PMID41431550
PMCPMC12718651

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.