ArticleCureus2025
Evaluating the Effects of Various Antioxidants on Dentinal Tubule Penetrability of a Resin-Based Sealer: A Confocal Laser Microscopic Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background This study aimed to evaluate the effects of various antioxidants on the dentinal tubule penetrability of a resin-based sealer using confocal laser microscopy. Methodology A total of 60 extracted human teeth were decoronated and prepared using Protaper Gold rotary files. The canals were irrigated sequentially with 3% sodium hypochlorite, 17% ethylenediaminetetraacetic acid, and distilled water. Samples were randomly divided into the following four groups (n = 15) based on the antioxidant used: Group 1 - control (no antioxidant), Group 2 - 6.5% proanthocyanidin, Group 3 - 34% cashew nut shell liquid, and Group 4 - 10% lycopene. Randomization was performed using a computer-generated random sequence to ensure unbiased specimen allocation. Following irrigation and drying, canals were obturated using AH Plus resin sealer mixed with Rhodamine B dye. Transverse sections were then examined under a confocal laser scanning microscope to assess sealer penetration. Data were statistically analyzed using one-way analysis of variance and Kruskal-Wallis tests. Results Group 4 (10% lycopene) demonstrated the greatest dentinal tubule penetration (359.00 ± 1.73 µm), followed by Group 2 (6.5% proanthocyanidin) (287.86 ± 1.55 µm) and Group 3 (34% cashew nut shell liquid) (261.00 ± 1.85 µm). The control group (Group 1) exhibited the least penetration (230.00 ± 1.92 µm). The differences among the groups were statistically significant (p < 0.05). Conclusion This study provides new evidence that antioxidant application enhances resin sealer penetration, potentially improving long-term root canal sealing efficacy. Within the limitations of this in vitro study, 10% lycopene exhibited the highest dentinal tubule penetrability of resin-based sealer, whereas the control group without antioxidant treatment showed the lowest. Antioxidant application may enhance resin sealer penetration and potentially improve the bonding interface.
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