Evidence map›Paper›PMID 41431348›Full record

ArticlePediatric blood & cancer2026

Evaluating the Genetic Overlap Between Congenital Heart Disease and Neuroblastoma Risk.

Ji Yun Tark, Alexander Renwick, Yao Yu, Aniko Sabo, Andrew F Olshan, Sharon E Plon, Chad D Huff, Philip J Lupo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric blood & cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ji Yun TarkSection of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.ORCID https://orcid.org/0000-0003-3233-5967
Alexander RenwickDepartment of Statistics, Rice University, Houston, Texas, USA.
Yao YuDepartment of Epidemiology, UT MD Anderson Cancer Center, Houston, Texas, USA.
Aniko SaboHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.
Andrew F OlshanDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Sharon E PlonDivision of Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Chad D HuffDepartment of Epidemiology, UT MD Anderson Cancer Center, Houston, Texas, USA.
Philip J LupoDivision of Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.

Funding

Molecular epidemiology of acute lymphoblastic leukemia in children with Down syndromeR01CA249867 · NCI · BAYLOR COLLEGE OF MEDICINE · PI LUPO, PHILIP, RABIN, KAREN R · 2020 to 2024
$4.2M
Qualification and Deployment of Imaging Biomarkers of Cancer Treatment ResponseU01CA190214 · NCI · STANFORD UNIVERSITY · PI RUBIN, DANIEL L · 2015 to 2020
$3.1M
Genetic Susceptibility Factors in the Etiology of NeuroblastomaR01CA132887 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI OLSHAN, ANDREW · 2008 to 2012
$2.8M
Integrating Epidemiologic and Genomic Data to Elucidate the Genetic Overlap Between Congenital Anomalies and Pediatric CancerR01CA284531 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Chad Daniel Huff, Philip Lupo · 2023 to 2026
$1.9M
High Memory High-Performance Computer Cluster for Biomedical ResearchS10OD032185 · OD · BAYLOR COLLEGE OF MEDICINE · PI HILSENBECK, SUSAN G. · 2022 to 2022
$596k
NCI NIH HHS R01 CA132887NCI NIH HHS R01 CA249867NCI NIH HHS R01 CA284531NCI NIH HHS U01 CA190214NIH HHS S10 OD032185
6 · The paper itself

Abstract

Children with congenital heart disease (CHD) have elevated neuroblastoma (NB) risk, potentially due to shared neural crest origins. We analyzed rare exonic de novo single-nucleotide variants in 702 CHD and 454 NB trios from the Neuroblastoma Epidemiology in North America Study, Gabriella Miller Kids First Program, and a published cohort. Seven genes, including CHD risk genes POGZ and LZTR1 (linked to Noonan syndrome and Schwannomatosis), showed nominal (p < 0.05) enrichment in both cohorts. CIC, IREB2, POGZ, and PCDHG cluster are associated with neurodevelopmental disorders, supporting shared developmental mechanisms. Findings warrant investigation of pathways linking congenital anomalies and childhood cancer.

Indexed as

Genetic Predisposition to DiseaseHeart Defects, CongenitalNeuroblastomaPolymorphism, Single NucleotideChildChild, PreschoolFemaleHumansInfantMalePrognosisbirth defectschildhood cancercongenital heart diseaseneuroblastomapleiotropyshared genetics

Identifiers

PMID41431348
PMCPMC13449798

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.