Evidence map›Paper›PMID 41431345›Full record

ArticleInfluenza and other respiratory viruses2025

Seasonal Influenza Vaccine 2021/2022 Provides Limited Cross Reactivity Against Contemporary Swine Influenza A Virus Strains in Spain.

Paloma Encinas, Antonio Lalueza-Blanco, Ana Isabel García-Vaquero, Martha I Nelson, Adolfo García-Sastre, Gustavo Del Real

Abstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paloma EncinasDepartment of Biotechnology, National Institute of Agricultural and Food Research and Technology (INIA-CSIC), Madrid, Spain.ORCID https://orcid.org/0000-0001-9596-8070
Antonio Lalueza-BlancoDepartment of Internal Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain.
Ana Isabel García-VaqueroOccupational Health Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
Martha I NelsonNational Center for Biotechnology Information, National Library of Medicine National Institutes of Health, Bethesda, Maryland, USA.
Adolfo García-SastreGlobal Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Gustavo Del RealDepartment of Biotechnology, National Institute of Agricultural and Food Research and Technology (INIA-CSIC), Madrid, Spain.ORCID https://orcid.org/0000-0002-8171-2274

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00014 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2021 to 2025
$62.6M
NIAID NIH HHS 75N93021C00014
6 · The paper itself

Abstract

Swine influenza A viruses (SIVs) pose a zoonotic risk, with variants detected in humans in Europe. This study evaluated the efficacy of the 2021/2022 seasonal influenza vaccine against SIVs. Forty-six postvaccination human sera were tested via hemagglutination inhibition (HI) assay against Spanish SIV genotypes. Seroprotection rate (SPR, HI titer ≥ 40) was 76% (95% CI: 64-88) and 91% (95% CI: 83-99) for human vaccine strains H1 and H3, respectively. SPRs were 67% (95% CI: 53-81) for pandemic swine H1, 64% (95% CI: 50-78) for human seasonal-like H1, 17%-46% for Eurasian avian-like H1, 15% (95% CI: 5-25) for human seasonal-like H3 from the 1970s, and 83%-93% for human seasonal-like H3 from the 2000s SIVs.

Indexed as

Influenza A virusInfluenza, HumanInfluenza VaccinesOrthomyxoviridae InfectionsAdultAnimalsAntibodies, ViralCross ReactionsFemaleHemagglutination Inhibition TestsHumansInfluenza A Virus, H1N1 SubtypeMaleMiddle AgedSeasonsSpainAntibodies, ViralInfluenza Vaccinesinfluenza A viruspandemic riskreverse zoonosisswinevaccine

Identifiers

PMID41431345
PMCPMC12981525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.