ArticleBrain and behavior2025
Visceral Adiposity and Inflammation Index as Predictors of Stroke Risk in Middle and Older Age: A Cohort Study Across Blood Pressure Groups.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Uncoupling Systemic Inflammation from Body Mass Index: The Unseen Role of Visceral Adiposity and Metabolic Phenotypes-A Subgroup Analysis of the Nationwide OBREDI-TR Cohort.Journal of clinical medicine · 2026Article
- Visceral Adiposity and Inflammation Index as Predictors of Stroke Risk in Middle and Older Age: A Cohort Study Across Blood Pressure Groups.Brain and behavior · 2025Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveThe visceral adiposity and inflammation index (VAII) is a composite index that combines the visceral adiposity index (VAI) and high-sensitivity C-reactive protein (hs-CRP), both of which are associated with stroke risk. This study aimed to investigate the association between VAII and stroke risk, with a particular focus on different blood pressure (BP) statuses, sexes, and age groups.
methodsData from 8883 participants in the China Health and Retirement Longitudinal Study were analyzed. VAII levels were categorized into quartiles, and stroke incidence was assessed. Restricted cubic spline analysis was used to assess the association between VAII and stroke risk on the basis of sex, age, and BP status. Sensitivity analyses, including complete-case analysis, multiple imputation, and calculation of the E-value, were conducted to assess the robustness of the findings.
resultsDuring a median follow-up of 9 years, 827 participants (9.31%) developed stroke. In fully adjusted models, a 1-SD increase in VAII was associated with higher stroke risk (HR = 1.048, 95% CI: 1.009-1.089). Stroke incidence increases across VAII quartiles, with Q4 showing more than twice the risk of Q1 (HR = 2.138, 95% CI: 1.720-2.658). Associations were evident in elevated BP (Q4 vs. Q1: HR = 2.034) and hypertension groups (Q3: HR = 1.906; Q4: HR = 1.713), but not in normal BP. Stronger associations appeared in women and in adults aged 40-60 years. Restricted cubic splines indicated nonlinear relationships. Sensitivity analyses supported the robustness of these findings.
conclusionOur study revealed a significant nonlinear relationship between VAII and the risk of stroke. The association between VAII and stroke was nonlinear in individuals with elevated BP and hypertension. Additionally, a nonlinear relationship was observed between VAII and stroke risk in both males and females, as well as in middle-aged and older adults.
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