Evidence map›Paper›PMID 41431215›Full record

Trial reportJournal of clinical periodontology2026

The Effect of Periodontal Therapy on Renal Function and Diabetes Control in Patients With Chronic Kidney Disease. A Randomised Controlled Clinical Trial.

Spyridon K Kouris, Yiorgos A Bobetsis, Sophia Lionaki, Panagiotis N Kanellopoulos, George Maropoulos, Panagiotis A Koromantzos, Athanasios D Protogerou, Phoebus N Madianos

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Spyridon K KourisDepartment of Dentistry, Department of Periodontics, National and Kapodistrian University of Athens, School of Health Sciences, Athens, Greece.ORCID 0009-0007-1993-1613
Yiorgos A BobetsisDepartment of Dentistry, Department of Periodontics, National and Kapodistrian University of Athens, School of Health Sciences, Athens, Greece.
Sophia LionakiDepartment of Medicine, Division of Nephrology, National and Kapodistrian University of Athens, School of Health Sciences, Attikon General Hospital, Athens, Greece.ORCID 0000-0003-1643-8923
Panagiotis N KanellopoulosLaiko General Hospital, Athens, Greece.
George MaropoulosLaiko General Hospital, Athens, Greece.
Panagiotis A KoromantzosDepartment of Dentistry, Department of Periodontics, National and Kapodistrian University of Athens, School of Health Sciences, Athens, Greece.
Athanasios D ProtogerouDepartment of Medicine, Clinic & Laboratory of Pathophysiology, Cardiovascular Prevention & Research Unit, National and Kapodistrian University of Athens, School of Health Sciences, Athens, Greece.
Phoebus N MadianosDepartment of Dentistry, Department of Periodontics, National and Kapodistrian University of Athens, School of Health Sciences, Athens, Greece.

Funding

Colgate-Palmolive Company
6 · The paper itself

Abstract

aimTo investigate the effect of non-surgical periodontal therapy (NSPT) on renal function and glycaemic control in chronic kidney disease (CKD) patients over a 6-month observation period, through a randomised clinical trial (RCT). MATERIALS AND

methodsA total of 53 patients participated: 27 in the intervention group (IG) and 26 in the control group (CG). Outcomes included estimated glomerular filtration rate (eGFR, calculated using serum creatinine or both serum creatinine and cystatin-C), urine albumin to urine creatinine ratio (uACR) and serum high-sensitivity C-reactive protein (hsCRP) levels. Glycaemic control was assessed using HbA1c levels in patients with diabetes mellitus (DM).

resultsIntra-group ΔeGFR levels were 10.26 mL/min/1.73 m

conclusionDespite its limitations, this RCT shows that NSPT enhances renal function-increasing eGFR and decreasing hsCRP-and improves glycaemic control in CKD patients with DM.

Indexed as

KidneyRenal Insufficiency, ChronicAdultAgedAlbuminuriaBlood GlucoseC-Reactive ProteinCreatinineCystatin CFemaleGlomerular Filtration RateGlycated HemoglobinGlycemic ControlHumansMaleMiddle AgedBlood GlucoseC-Reactive ProteinCreatinineCystatin CGlycated Hemoglobinchronic kidney diseaseCRPdiabetes mellitusperiodontal therapy

Identifiers

PMID41431215
PMCPMC12890459

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.