Evidence map›Paper›PMID 41431166›Full record

ReviewBiological reviews of the Cambridge Philosophical Society2026

Molecular bases of insect odorant receptor function: specificity and evolution.

Zibo Li, Abhinob Baruah, Sridevi Bhamidipati, Nicolas Montagné, Emmanuelle Jacquin-Joly, Camille Meslin

Abstract readReview
In one paragraph

Review in Biological reviews of the Cambridge Philosophical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Decoding channel pore dynamics mechanism inBioinformatics advances · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zibo Li *Sorbonne Université, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Centre National de la Recherche Scientifique, Institut de Recherche pour le Développement, Université Paris-Est-Créteil-Val-de-Marne, Université Paris Cité, Institut d'Ecologie et des Sciences de l'Environnement de Paris, Versailles cedex, 78026, France.ORCID 0000-0001-6167-965X
Abhinob Baruah *Sorbonne Université, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Centre National de la Recherche Scientifique, Institut de Recherche pour le Développement, Université Paris-Est-Créteil-Val-de-Marne, Université Paris Cité, Institut d'Ecologie et des Sciences de l'Environnement de Paris, Versailles cedex, 78026, France.ORCID 0000-0001-5985-5677
Sridevi Bhamidipati *Sorbonne Université, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Centre National de la Recherche Scientifique, Institut de Recherche pour le Développement, Université Paris-Est-Créteil-Val-de-Marne, Université Paris Cité, Institut d'Ecologie et des Sciences de l'Environnement de Paris, Versailles cedex, 78026, France.
Nicolas MontagnéSorbonne Université, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Centre National de la Recherche Scientifique, Institut de Recherche pour le Développement, Université Paris-Est-Créteil-Val-de-Marne, Université Paris Cité, Institut d'Ecologie et des Sciences de l'Environnement de Paris, Versailles cedex, 78026, France.ORCID 0000-0001-8810-3853
Emmanuelle Jacquin-JolySorbonne Université, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Centre National de la Recherche Scientifique, Institut de Recherche pour le Développement, Université Paris-Est-Créteil-Val-de-Marne, Université Paris Cité, Institut d'Ecologie et des Sciences de l'Environnement de Paris, Versailles cedex, 78026, France.ORCID 0000-0002-6904-2036
Camille MeslinSorbonne Université, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Centre National de la Recherche Scientifique, Institut de Recherche pour le Développement, Université Paris-Est-Créteil-Val-de-Marne, Université Paris Cité, Institut d'Ecologie et des Sciences de l'Environnement de Paris, Versailles cedex, 78026, France.ORCID 0000-0003-2120-0936

Funding

Agence Nationale de la Recherche ANR-22-CE13-0013
6 · The paper itself

Abstract

Insect odorant receptors (ORs) are a class of chemoreceptors that insects use to detect volatile cues in their environment. In recent years, major advances in the field of structural biology have made it possible to obtain the first structures of insect ORs. In this review, we place molecular evidence of OR function into the context of their three-dimensional structure, focusing on both tuning ORs and their co-receptor, Orco, as well as their interaction. We also used AlphaFold2 to model the structures of several deorphanized receptors and mapped the experimentally identified residues important for function, revealing putative functional hotspots. We discuss several efficient methods for functional evolution studies and propose emerging technologies that may open avenues for further research and innovation.

Indexed as

Evolution, MolecularInsectaInsect ProteinsReceptors, OdorantAnimalsBiological EvolutionInsect ProteinsReceptors, Odorantevolutionligand binding pocketodorant receptorsite‐directed mutationstructure–function

Identifiers

PMID41431166
PMCPMC12965853

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.