ArticleRespirology (Carlton, Vic.)2026
Prognostic Value of a Cardiopulmonary Exercise Testing-Derived Summed Score in Idiopathic Pulmonary Fibrosis and Connective Tissue Disease-Associated Interstitial Lung Disease: A Prospective Cohort Study.
Article in Respirology (Carlton, Vic.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06476470 (A Prospective Multi-center Registry for Fibrotic Lung Disease, Focusing on Clinical Phenotype, Physical Parameters, Image Analysis, and Precision Medicine in Taiwan), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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A Prospective Multi-center Registry for Fibrotic Lung Disease, Focusing on Clinical Phenotype, Physical Parameters, Image Analysis, and Precision Medicine in Taiwan
Who cites it
1 citing paper in PubMed.
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Authors and funding
7 authors.
Funding
Abstract
BACKGROUND AND
objectiveOur previous study demonstrated that a summed score derived from six cardiopulmonary exercise testing (CPET) parameters could predict 1-year mortality in patients with interstitial lung disease (ILD). However, its long-term prognostic value across different ILD aetiologies remains unclear. This study aimed to assess the predictive performance of CPET-derived parameters for long-term outcomes in patients with idiopathic pulmonary fibrosis (IPF) and connective tissue disease-associated ILD (CTD-ILD).
methodsIn this prospective cohort study, 210 patients newly diagnosed with ILD between 2018 and 2022 at a tertiary medical centre underwent CPET. A CPET-derived summed score was evaluated for its association with a composite outcome of all-cause mortality or lung transplantation. Cox regression and receiver operating characteristic curve analyses were used to examine predictive ability and identify the optimal cutoff value. Kaplan-Meier survival analysis and log-rank tests compared event-free survival in IPF and CTD-ILD patients.
resultsA summed score incorporating five CPET-derived variables was an independent predictor of the composite outcome. Patients with scores of 2-5 had markedly lower event-free survival (44.2%) than those with scores of 0-1 (88.3%). The score demonstrated consistent predictive value in both IPF and CTD-ILD.
conclusionThe CPET-derived summed score is a useful prognostic tool for predicting all-cause mortality or the need for lung transplantation in newly diagnosed ILD patients. It also retains predictive accuracy for long-term outcomes in both IPF and CTD-ILD. External validation in other ILD subtypes is warranted.
trial registrationClinicalTrials.gov identifier: NCT06476470.
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