Observational studyArthritis care & research2026
The Relation of Within-Day Physical Activity Patterns With All-Cause Mortality in Adults With Knee Osteoarthritis: Findings From the Osteoarthritis Initiative.
Observational study in Arthritis care & research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00080171 (Osteoarthritis Initiative), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Osteoarthritis Initiative (OAI): A Knee Health Study
Who cites it
2 citing papers in PubMed.
- Within-day activity patterns in knee osteoarthritis: frailty signal or treatment marker? Comment on the article by Liles et al.Arthritis care & research · 2026Article
- Reply.Arthritis care & research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveThere is an urgent need to identify clinical markers that can help physicians determine when additional treatment is necessary to manage the symptoms of knee osteoarthritis (OA). Patterns of physical activity that occur within a day, eg, low activity in the morning and/or evening, may be a novel means to identify treatment need, given that symptoms may reduce daily activity at specific times of the day. The purpose of this study is to explore the relationship between within-day patterns of physical activity and all-cause mortality in adults with or at high risk for knee OA.
methodsWe performed a secondary analysis of the Osteoarthritis Initiative (NCT00080171). Our exposure was within-day patterns of physical activity using a multidimensional (14-hour) multilevel (4-day) functional principal component analysis to analyze accelerometer data from analytic baseline. The outcome was all-cause mortality assessed up to eight years. Kaplan-Meier survival curves and Cox proportional hazards regressions were used to calculate adjusted hazard ratios (aHR).
resultsThere were 1,927 adults with or at high risk for knee OA included in this analysis. We identified four primary within-day activity patterns accounting for around 82% of sample variability. Participants who demonstrated low levels of activity in the morning and evening had 2.09 times the risk of death compared with those demonstrating the average activity pattern of the sample (aHR 2.09, 95% confidence interval 1.15-3.80).
conclusionUnique within-day patterns of physical activity were associated with risk of death. Those with inactivity in the morning and evening were at increased risk for death.
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Registered trials
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