ArticleClinical endoscopy2026
Endoscopic ultrasound-guided plugged liver biopsy using a fine-needle biopsy needle and coils in patients with deranged coagulation parameters: proof of concept study for feasibility and safety from India.
Article in Clinical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Advancing endoscopic ultrasound-guided liver biopsy through coil-based tract embolization: a new safety paradigm.Clinical endoscopy · 2026Article
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12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundEndoscopic ultrasound (EUS)-guided liver biopsy in patients with coagulopathy remains unexplored mainly because of the lack of effective hemostatic techniques in the event of post-biopsy bleeding. This study evaluated the feasibility and safety of a novel technique, EUS-guided plugged liver biopsy (EUS-PLB), which incorporates coil embolization for tract hemostasis.
methodsIn a pilot study, 20 patients with coagulopathy (platelets 20,000-50,000/μL or international normalized ratio 1.5-2.5) underwent EUS-PLB using a modified heparinized wet suction technique. Hemostasis was achieved via real-time EUS-guided deployment of 1 to 2 coils (0.035-inch, 5-cm length, 3-mm diameter coil) into the needle tract. Outcomes included technical and clinical success, sample adequacy, and adverse events.
resultsCoil placement was technically successful in all patients. Persistent needle-tract bleeding occurred in five cases and was effectively controlled. The clinical success rate for preventing significant bleeding (early or delayed) was 100%. Adequate biopsy samples were obtained in 18/20 patients (90%), with a mean total specimen length of 3.34±0.88 cm and median complete portal tracts of 18 (range, 6-25). Histological diagnosis was possible in 95% of cases. One patient experienced a mild adverse event (5%).
conclusionsThis novel EUS-PLB technique with coil embolization may offer a safe and effective biopsy solution for patients with coagulopathy and warrants further investigation.
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