ArticleBMC pediatrics2025
Association of endocrine autoantibodies (anti-TPO, anti-GAD, anti-insulin) with histopathological severity in pediatric Celiac disease: a retrospective cohort study.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeCeliac disease (CD) is an autoimmune disorder triggered by gluten ingestion, characterized by the development of specific autoantibodies. An increased incidence of type 1 diabetes mellitus (T1DM) and autoimmune thyroid disease (ATD) has been reported in patients with CD. However, there is a gap in the literature regarding the association between the severity of CD and the levels of these autoantibodies. This study aimed to evaluate the relationship between the severity of CD and autoantibody levels associated with T1DM and ATD.
methodsPatients diagnosed with CD between 2010 and 2023 and followed for at least two years were included, provided that endocrine autoantibody levels were available. Patients were evaluated based on their demographic, clinical, biochemical, and pathological data.
resultsA total of 248 patients were analyzed, with a median age of 11 years (Range: 3-18); 159 (64.1%) were female. Endocrine autoantibodies were found to be positive in 51 patients (20.6%). All patients with positive autoantibodies were aged 10 years or older (p < 0.001). Total villous atrophy was observed in 94 patients (37.9%) and 94 patients (37.9%) had findings consistent with Marsh 3 C. In multivariate analysis, the presence of endocrine autoantibodies emerged as the only independent factor associated with an increased Marsh grade (p < 0.001).
conclusionOur study demonstrated that the presence of autoantibodies associated with T1DM and ATD was correlated with more severe histopathological findings in patients with CD. There is a need for prospective studies investigating the role of these autoantibodies in predicting the prognosis of CD.
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