Evidence map›Paper›PMID 41430642›Full record

ArticleThe Journal of organic chemistry2026

Synthesis of Quinolizidine-Based 1,4-Azaphosphinines via Cyclization of Heteroarylmethyl(alkynyl)phosphinates.

Martin Kos, Tomáš Beránek, Jaroslav Žádný, Natálie Kochová, Karolína Václavíková, Illia Panov, Jan Storch, Ivana Císařová, Jan Sýkora, Vladimír Církva

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Martin KosDepartment of Materials Chemistry, Research Group of Advanced Materials and Organic Synthesis, Institute of Chemical Process Fundamentals of the Czech Academy of Sciences, v. v. i., Rozvojová 135, 165 00 Prague 6, Czech Republic.ORCID 0000-0001-6134-8922
Tomáš BeránekDepartment of Materials Chemistry, Research Group of Advanced Materials and Organic Synthesis, Institute of Chemical Process Fundamentals of the Czech Academy of Sciences, v. v. i., Rozvojová 135, 165 00 Prague 6, Czech Republic.ORCID 0000-0002-2393-2084
Jaroslav ŽádnýDepartment of Materials Chemistry, Research Group of Advanced Materials and Organic Synthesis, Institute of Chemical Process Fundamentals of the Czech Academy of Sciences, v. v. i., Rozvojová 135, 165 00 Prague 6, Czech Republic.ORCID 0000-0002-3737-3519
Natálie KochováDepartment of Materials Chemistry, Research Group of Advanced Materials and Organic Synthesis, Institute of Chemical Process Fundamentals of the Czech Academy of Sciences, v. v. i., Rozvojová 135, 165 00 Prague 6, Czech Republic.
Karolína VáclavíkováDepartment of Materials Chemistry, Research Group of Advanced Materials and Organic Synthesis, Institute of Chemical Process Fundamentals of the Czech Academy of Sciences, v. v. i., Rozvojová 135, 165 00 Prague 6, Czech Republic.
Illia PanovDepartment of Materials Chemistry, Research Group of Advanced Materials and Organic Synthesis, Institute of Chemical Process Fundamentals of the Czech Academy of Sciences, v. v. i., Rozvojová 135, 165 00 Prague 6, Czech Republic.
Jan StorchDepartment of Materials Chemistry, Research Group of Advanced Materials and Organic Synthesis, Institute of Chemical Process Fundamentals of the Czech Academy of Sciences, v. v. i., Rozvojová 135, 165 00 Prague 6, Czech Republic.
Ivana CísařováDepartment of Inorganic Chemistry, Faculty of Science, Charles University in Prague, Hlavova 2030, 128 40 Prague 2, Czech Republic.
Jan SýkoraDepartment of Analytical Chemistry, Faculty of Chemical Engineering, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic.ORCID 0000-0002-2930-8880
Vladimír CírkvaDepartment of Materials Chemistry, Research Group of Advanced Materials and Organic Synthesis, Institute of Chemical Process Fundamentals of the Czech Academy of Sciences, v. v. i., Rozvojová 135, 165 00 Prague 6, Czech Republic.ORCID 0000-0001-5351-4003

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intramolecular hydroarylation of (phenylethynyl)phosphinates represents a powerful strategy for constructing six-membered phosphorus heterocycles. In this study, we report a silver-catalyzed cyclization protocol that enables the efficient synthesis of 1,4-aza-phosphorus heterocycles under mild conditions. The approach demonstrates broad substrate tolerance, affording full conversion across more than 30 derivatives. Dearomatization of pyridine leads to the formation of previously unreported quinolizidine-based 1,4-azaphosphinine scaffolds. These novel phosphorus heterocycles expand the structural diversity of phosphorus-containing frameworks and open new opportunities in the chemistry of functional heterocycles.

Identifiers

PMID41430642
PMCPMC12797286

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.