Evidence map›Paper›PMID 41430581›Full record

ArticleBMC infectious diseases2025

Utility of the meningoencephalitis panel in management of neonates with temperature instability.

Brittany Player, Peter L Havens, Michelle L Mitchell, Sheila Swartz, Amy Y Pan, Sai Alekha Challa, Glenn Bushee, Anna R Huppler

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Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Brittany PlayerDepartment of Pediatrics, Section of Infectious Diseases, Medical College of Wisconsin, Children's Wisconsin, PO Box 1997, Milwaukee, WI, 53201-1997, USA. bplayer@mcw.edu.
Peter L HavensDepartment of Pediatrics, Section of Infectious Diseases, Medical College of Wisconsin, Children's Wisconsin, PO Box 1997, Milwaukee, WI, 53201-1997, USA.
Michelle L MitchellDepartment of Pediatrics, Section of Infectious Diseases, Medical College of Wisconsin, Children's Wisconsin, PO Box 1997, Milwaukee, WI, 53201-1997, USA.
Sheila SwartzDepartment of Pediatrics, Section of Hospital Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Amy Y PanDepartment of Pediatrics, Division of Bioinformatics and Quantitative Child Health, Medical College of Wisconsin, Milwaukee, WI, USA.
Sai Alekha ChallaDepartment of Pediatrics, Division of Bioinformatics and Quantitative Child Health, Medical College of Wisconsin, Milwaukee, WI, USA.
Glenn BusheeDepartment of Quality and Health Outcomes, Children's Wisconsin, Milwaukee, WI, USA.
Anna R HupplerDepartment of Pediatrics, Section of Infectious Diseases, Medical College of Wisconsin, Children's Wisconsin, PO Box 1997, Milwaukee, WI, 53201-1997, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFor infants aged ≤ 60-days evaluated for temperature instability, we sought to ascertain if use of a multiplex meningoencephalitis panel (MEP) decreased length of hospital stay (LOS), antimicrobial length of therapy (LoT), and use of other molecular testing.

methodsThis was a retrospective cohort study of infants aged ≤ 60-days hospitalized for temperature instability between 1/2012 and 1/2022. Patients were included if blood and cerebrospinal fluid (CSF) cultures were negative for bacterial infection. Patients were categorized into groups by MEP availability and use. LOS, LoT, and use of other molecular tests were compared by MEP usage group.

resultsA total of 2076 patients met study criteria; there was no difference between groups regarding sex, race, ethnicity, or age at admission. During the period of MEP availability (2017–2022), the test was performed for 156/1101 (14%) patients. Compared to eligible patients without the MEP performed, MEP use was associated with longer LOS (57.7 vs. 47.3 h, p < 0.0001) and longer LoT (37.4 vs. 35.5 h, p < 0.0001). Use of the MEP was also associated with performance of additional molecular tests. Patients with CSF obtained after antimicrobial initiation had longer LOS compared to those with CSF obtained before antimicrobials were initiated, and MEP use did not mitigate that.

conclusionsYoung infants without bacterial infection by blood or CSF culture that had the MEP performed had longer length of hospital stays, longer duration of antimicrobial therapy, and more molecular testing performed compared to those without the MEP performed. Further research focusing on clinical scenarios where MEP use may be most beneficial for infants with temperature instability is needed. CLINICAL TRIAL: Not applicable.

Indexed as

FeverMeningoencephalitisAnti-Bacterial AgentsFemaleHumansInfantInfant, NewbornLength of StayMaleRetrospective StudiesAnti-Bacterial AgentsAntimicrobialsDiagnostic stewardshipMeningoencephalitisMultiplex PCRNeonatal fever

Identifiers

PMID41430581
PMCPMC12750577

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